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Organism Commentary Reference
Danio rerio- 693977
Dictyosteliumstrains AX3 and DH1 653180
Dictyostelium discoideum- 649701
Dictyostelium discoideumisoforms PDE5, PDE6 678053
Dictyostelium discoideumstrains NC4, XP55 and NP377 653179
Drosophila melanogaster- 667501, 690833
Drosophila sp. (in: flies)generation of transgenic animals with targeted expression of DmPDE6 to tubule type I (principal) cells. This reveals localization of DmPDE6 primarily at the apical membranes. Overexpression of DmPDE6 results in elevated cG-PDE activity and decreased tubule cGMP content. Such targeted overexpression of DmPDE6 creates a novel phenotype that manifests itself in inhibition of the active transport and efflux of cGMP by tubules 667521
Gallus gallus- 669288, 669954, 693132
Homo sapiens- 650811, 651322, 652763, 653097, 653343, 667119, 667433, 668990, 669021, 669209, 670025, 670287, 670332, 670983, 671011, 691533, 691945, 692724, 693333, 694879, 710776, 710867, 711409, 711553, 711554, 711557, 711619, 711624, 711652, 711841, 711934, 711948, 712091, 712187, 712394, 712630, 712671, 712841, 713068, 713513, 713514, 750045, 751213
Homo sapiensisoenzymes PDE5A1, PDE5A2 and PDE5A3 649549
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