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Literature summary extracted from

  • Day, J.P.; Dow, J.A.T.; Houslay, M.D.; Davies, S.A.
    Cyclic nucleotide phosphodiesterases in Drosophila melanogaster (2005), Biochem. J., 388, 333-342.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.4.17 expression in Drosophila S2 cells, PDE1 Drosophila melanogaster
3.1.4.17 expression in Drosophila S2 cells, PDE11 Drosophila melanogaster
3.1.4.35 expression in Drosophila S2 cells Drosophila melanogaster

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.17 sildenafil IC50: IC50: 0.00012 mM, PDE11; IC50: IC50: 0.0013 mM, PDE1 Drosophila melanogaster
3.1.4.17 zaprinast IC50: 0.0016 mM, PDE11; IC50: 0.071 mM, PDE1 Drosophila melanogaster
3.1.4.35 sildenafil IC50: IC50: 0.000025 mM Drosophila melanogaster
3.1.4.35 zaprinast IC50: 0.00065 mM Drosophila melanogaster

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.4.17 0.006
-
 3',5'-cGMP PDE11 Drosophila melanogaster
3.1.4.17 0.0153
-
 3',5'-cGMP PDE1 Drosophila melanogaster
3.1.4.17 0.0185
-
 3',5'-cAMP PDE11 Drosophila melanogaster
3.1.4.17 0.0205
-
 3',5'-cAMP PDE1 Drosophila melanogaster
3.1.4.35 0.037
-
 3',5'-cGMP
-
 Drosophila melanogaster

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.17 Drosophila melanogaster
-
-
-
3.1.4.35 Drosophila melanogaster
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.17 3',5'-cAMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 Drosophila melanogaster 5'-AMP
-
 ?
3.1.4.17 3',5'-cAMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 Drosophila melanogaster 5'-AMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE1 Drosophila melanogaster 5'-GMP
-
 ?
3.1.4.17 3',5'-cGMP + H2O specific for 3',5'-cGMP and 3',5'-cAMP, PDE11 Drosophila melanogaster 5'-GMP
-
 ?
3.1.4.35 3',5'-cGMP + H2O specific for 3',5'-cGMP Drosophila melanogaster 5'-GMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.17 dual-specificity PDE
-
 Drosophila melanogaster
3.1.4.17 PDE1
-
 Drosophila melanogaster
3.1.4.17 PDE11
-
 Drosophila melanogaster
3.1.4.35 cG-PDE
-
 Drosophila melanogaster
3.1.4.35 cGMP-specific PDE
-
 Drosophila melanogaster
3.1.4.35 PDE6
-
 Drosophila melanogaster

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.4.17 0.00012
-
 IC50: 0.00012 mM, PDE11 Drosophila melanogaster sildenafil
3.1.4.17 0.0013
-
 IC50: 0.0013 mM, PDE1 Drosophila melanogaster sildenafil
3.1.4.17 0.0016
-
 IC50: 0.0016 mM, PDE11 Drosophila melanogaster zaprinast
3.1.4.17 0.071
-
 IC50: 0.071 mM, PDE1 Drosophila melanogaster zaprinast
3.1.4.35 0.000025
-
 IC50: 0.000025 mM Drosophila melanogaster sildenafil
3.1.4.35 0.00065
-
 IC50: 0.00065 mM Drosophila melanogaster zaprinast