EC Number   |
Application |
Reference |
|---|
   5.2.1.8 | agriculture |
use of leaf enzyme activity as a marker for water stress tolerance in sorghum |
682273 |
| 5.2.1.8 | analysis |
fluorescent probe 6-(dimethylamino)-2-naphthoyl-Ala-Ala-(cis)-Pro-Phe-4-nitroanilide can be used for imaging active peptidyl-prolyl cis/trans isomerases in live cells |
747512 |
| 5.2.1.8 | analysis |
high-throughput screening method for isoform FKBP12 binding based on the decrease of a fluorescence signal generated by a small molecule fluorescent FKBP12 ligand bound to the protein and measured in the presence of inhibitor |
678627 |
| 5.2.1.8 | analysis |
the enzyme weakly catalyzes some protein processes which are rate-limited by proline isomerization, but probably exhibits no measurable catalysis towards others. This somewhat limits the usefulness of the enzyme as a diagnostic reagent for proline isomeri |
2517 |
| 5.2.1.8 | medicine |
cyclophilin B is critical for the efficient replication of the hepatitis C virus genome. enzyme interacts with the viral RNA polymerase NS5B to directly stimulate its RNA binding activity |
662835 |
| 5.2.1.8 | medicine |
CYPJ expression is upregulated in over 60% hepatocellular carcinoma tissues. CYPJ is found in the whole cell of hepatocellular carcinoma tissues with preferential location at the cell nucleus |
749058 |
| 5.2.1.8 | medicine |
enzyme isoform PPIL1 is frequently overexpressed in colon cancer cells. Wild-type PPIL1 shows a growth-promoting effect on NIH-3T3 and HEK-293 cells. Consistently, transfection with its siRNA reduces gene expression and retards growth of colon cancer cells. Enzyme interacts with SNW1/SKI-binding protein and with stathmin |
679270 |
| 5.2.1.8 | medicine |
isoform CypA is necessary for the prolactin-induced activation of Janus-activated kinase 2 and the progression of human breast cancer. Direct correlation between the levels of activity of CypA and the extent of prolactin-induced signaling and gene expression. A CypA-mediated conformational change withi the prolactin r/Janus-activated kinase 2 complex is required for prolactin-induced transduction and function |
691626 |
| 5.2.1.8 | medicine |
isoform Pin1 is a critical regulator of p27kip1 through inhibition of Forkhead box O, FOXO4. Oxidative stress induces binding of Pin1 to FOXO4 thereby attenuating its monoubiquitination. Pin1 prevents nuclear FOXO4 accumulation and acts on FOXO through stimulation of the activity of the deubiquitinating enzyme HAUSP/USP7 |
691625 |
| 5.2.1.8 | medicine |
PIN1 inhibition dramatically reduces the tumor volume in a subcutaneous mouse xenograft model and angiogenesis as well as hypoxia-induced transcriptional activity of hypoxia-inducible factor HIF-1alpha |
749076 |
