EC Number   |
Application |
Reference |
|---|
   2.7.7.84 | analysis |
modified coupled spectrophotometric assay to detect 2-5 oligoadenylate synthetase enzyme activity in prostate cell lines as a model system. The phosphates generated by the OAS enzymatic reaction are coupled with conversion of the substrate 2-amino-6-mercapto-7-methylpurine ribonucleoside to a purine base product, 2-amino-6-mercapto-7-methylpurine and ribose1-phosphate via a purine nucleoside phosphorylase |
737800 |
| 2.7.7.84 | medicine |
in lymphoid cell of thymus, expression increases during inflammatory processes under ulcerogenic conditions caused by stress factors. Omeprazole treatment leads to increase in enzymic activity in thymocytes under stress, but not in the absence of stress. Omeprazole treatment does not increase enzymic activity in lymphoid cells of spleen |
739647 |
| 2.7.7.84 | medicine |
isoforms OAS1 p46 and OAS3 p100 mediate the RNase L-dependent antiviral activity against hepatitis C virus. The expression of isoform p46 shows a notable inhibition for the protein expression from HCV JFH-1 in an RNase L-dependent manner, whereas no inhibitory effect is produced by the p42, p48 or p52 isoforms of OAS1 |
738223 |
| 2.7.7.84 | medicine |
secreted OAS2 is capable of regulating T-cell receptor CD3-zeta chain expression. Incubation of T-cells with cell-free supernatants of oral tumours or recombinant human OAS2 induces caspase-3 activation, which results in CD3-zeta chain down-regulation |
738357 |
