Literature summary for 2.7.7.84 extracted from

Kwon, Y.; Kang, J.; Hwang, S.; Ahn, B.
The ribonuclease l-dependent antiviral roles of human 2',5'-oligoadenylate synthetase family members against hepatitis C virus (2013), FEBS Lett., 587, 156-164.

Search for more literature for 2.7.7.84

Application

Application	Comment	Organism
medicine	isoforms OAS1 p46 and OAS3 p100 mediate the RNase L-dependent antiviral activity against hepatitis C virus. The expression of isoform p46 shows a notable inhibition for the protein expression from HCV JFH-1 in an RNase L-dependent manner, whereas no inhibitory effect is produced by the p42, p48 or p52 isoforms of OAS1	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00973	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	OAS1 and OAS3 transcripts are constitutively expressed	Homo sapiens	-
Huh-7 cell	OAS1 and OAS3 transcripts are constitutively expressed	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
OAS1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	expression is significantly induced following interferon treatment	up

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Release 2023.1 (January 2023)