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Literature summary for 2.7.7.84 extracted from

  • Dar, A.A.; Pradhan, T.N.; Kulkarni, D.P.; Shah, S.U.; Rao, K.V.; Chaukar, D.A.; DCruz, A.K.; Chiplunkar, S.V.
    Extracellular 2'5'-oligoadenylate synthetase 2 mediates T-cell receptor CD3-zeta chain down-regulation via caspase-3 activation in oral cancer (2016), Immunology, 147, 251-264.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine secreted OAS2 is capable of regulating T-cell receptor CD3-zeta chain expression. Incubation of T-cells with cell-free supernatants of oral tumours or recombinant human OAS2 induces caspase-3 activation, which results in CD3-zeta chain down-regulation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
T-cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
OAS2
-
 Homo sapiens