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Natural Substrates
Commentary (Nat. Sub.)
5.6.1.2
ATP + H2O + a dynein associated with a microtubule at position n
dynein is a motor protein that moves on microtubules using the energy of adenosine triphosphate hydrolysis
5.6.1.2
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cytoplasmic dynein may play structural and functional roles in the postsynaptic terminal
5.6.1.2
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dynein intermediate chain isoforms define dynein populations that are selectively recruited to transport distinct cargoes. Neurotrophin receptor tyrosine kinase B signaling endosomes are transported by cytoplasmic dynein containing the neuron-specific intermediate chain-1B isoform and not by dynein containing the ubiquitous intermediate chain-2C isoform. Organelles containing tyrosine kinase B also contain dynein with intermediate chain-1 but not intermediate chain-2 isoforms
5.6.1.2
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microtubules simultaneously accelerate the ATPase activity not only at the primary site but also at other site(s) in the dynein motor domain
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