EC Number   |
Natural Substrates |
|---|
   5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
dynein mediates retrograde neurofilament transport within axons and anterograde delivery of NFs from perikarya into axons |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
dynein-dynactin, Asp, and KLP10A have complex interdependent functions in spindle pole focusing and centrosome attachment |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
kinesin I and cytoplasmic dynein orchestrate glucose-stimulated insulin-containing vesicle movements in clonal MIN6 beta-cells. The majority of transport of large dense-core vesicles in beta-cells is mediated by kinesin I, whilst dyneien probably contrtibutes to the recovery of vesicles after rapid kiss-and-run exocytosis |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
Lmxdhc2.1 that encodes cytoplasmic dynein heavy chain 2.1 is an essentail gene in Leishmania |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
model in which both the stalk and the extreme C terminus of the dynein heavy chain control the rate-limiting step of product release in the dynein enzymatic cycle through long range allosteric mechanisms |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
the dynein light chain, Dlc1, is required preferentially for achiasmate segregation (segregation of homologous chromosomes in the absence of meiotic recombination), while the dynein heavy chain is required for meiotic chromosome segregation in both the presence and the absence of recombination |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
the LC7 light chains of Chlamydomonas flagellar dyneins interact with components required for both motor assembly and regulation |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
the majority of moving phagosomes are minus-end directed, the remainder moves towards microtubule plus-ends and a small subset moves bi-directionally. Minus-end movement showes pharmacological characteristics expected for dyneins, plus-end movement displayed pharmacological properties of kinesin |
| 5.6.1.2 | ATP + H2O + a dynein associated with a microtubule at position n |
cytoplasmic dynein is an AAA+ motor responsible for intracellular cargo transport and force generation along microtubules |
