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Information on EC 5.6.1.2 - dynein ATPase

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IUBMB Comments
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa).
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Word Map
  • 5.6.1.2
  • kinesins
  • cilia
  • spindle
  • cargo
  • myosin
  • actin
  • dynactin
  • retrograde
  • chlamydomonas
  • centrosome
  • microtubule-based
  • beat
  • slide
  • sliding
  • minus
  • doublet
  • radial
  • anterograde
  • microtubule-associated
  • endosomes
  • microtubule-dependent
  • anaphase
  • flagellum
  • kinetochore
  • spoke
  • urchin
  • dyskinesia
  • tetrahymena
  • immotile
  • kinesin-like
  • coiled-coil
  • microtubule-binding
  • interphase
  • intraflagellar
  • single-molecule
  • microtubular
  • plus-ends
  • actin-based
  • mechanochemical
  • ciliogenesis
  • sinusitis
  • left-right
  • aster
  • bronchiectasis
  • prometaphase
  • force-generating
  • mucociliary
  • nocodazole
  • medicine
  • aggresome
  • centriole
  • diagnostics
The enzyme appears in viruses and cellular organisms
Reaction Schemes
+
+
a dynein associated with a microtubule at position n
=
+
+
a dynein associated with a microtubule at position n-1 (toward the minus end)
Synonyms
AAA+ ATPase motor cytoplasmic dynein, axonemal dynein, cytoplasmic dynein heavy chain 2.1, cytoplasmic dynein heavy chain 2.2, dynein, dynein as chromosome motor, dynein ATPase, dynein complex motor, dynein I1, dynein light chain Tctex-1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + H2O + a dynein associated with a microtubule at position n = ADP + phosphate + a dynein associated with a microtubule at position n-1 (toward the minus end)
show the reaction diagram
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