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EC Number	Metals/Ions	Commentary	Reference
2.4.1.175	Ca2+	activates slightly	758683
2.4.1.175	Cd2+	activates	659262
2.4.1.175	Co2+	divalent cation is essential, Co2+ evokes the highest level of activity	659262
2.4.1.175	Fe2+	can partly substitute for Mn2+, 30.6% activity compared to Mn2+	638352
2.4.1.175	Mg2+	activates moderately	758683
2.4.1.175	Mg2+	can partly substitute for Mn2+, 30.7% activity compared to Mn2+	638352
2.4.1.175	Mg2+	required, 3fold activation at 1-10 mM	760033
2.4.1.175	Mn2+	-	638346, 638347, 638349
2.4.1.175	Mn2+	31% as effective as Co2 in reaction with chondroitin sulfate C11 and UDP-glucuronic acid, 64% as effective as Co2+ in reaction with chondroitin sulfate C10 and UDP-GalNAc	659262
2.4.1.175	Mn2+	activates	722689

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Release 2023.1 (January 2023)