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EC Number
Localization
Commentary
GeneOntology No.
Reference
2.3.1.286
cytoplasm
-
GO:0005737
AmiGO
QuickGO
738942
,
750703
2.3.1.286
cytoplasm
the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis
GO:0005737
AmiGO
QuickGO
729802
2.3.1.286
mitochondrion
-
GO:0005739
AmiGO
QuickGO
738108
,
738661
2.3.1.286
mitochondrion
SIRT3 is localized to the inner membrane of the mitochondria
GO:0005739
AmiGO
QuickGO
730840
2.3.1.286
mitochondrion
Sirt5 can be translocated into the mitochondrial intermembrane space, but also into the matrix
GO:0005739
AmiGO
QuickGO
730205
2.3.1.286
nuclear body
SIRT1 and p53 colocalize in nuclear bodies (punctate structures found in the nuclei of certain cells) upon upregulation of the promyelocytic leukemia protein
GO:0016604
AmiGO
QuickGO
729638
2.3.1.286
nucleus
-
GO:0005634
AmiGO
QuickGO
750703
2.3.1.286
nucleus
in the G2/M transition and in mitosis the enzyme is localized in association with chromatin
GO:0005634
AmiGO
QuickGO
729802
2.3.1.286
nucleus
SIRT1 is located in the nucleus of cerebral cortex neurons
GO:0005634
AmiGO
QuickGO
730103
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