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Information on EC 2.3.1.286 - protein acetyllysine N-acetyltransferase
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EC Tree
2.3.1.286 protein acetyllysine N-acetyltransferaseIUBMB Comments
The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
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Word Map
- 2.3.1.286
-
deacetylation
- resveratrol
-
nad+-dependent
- nicotinamide
- deacetylases
- endothelial
-
longevity
- peroxisome
- cardiac
- tnf
- obesity
-
proliferator-activated
- cardiovascular
- dismutase
- neurodegenerative
- chromatin
-
neuroprotective
-
lifespan
- sirna
- myocardial
-
amp-activated
- fibrosis
- adipose
-
polyphenolic
-
high-fat
- cardiomyocytes
-
forkhead
-
calorie
- alzheimer
- hdacs
-
obese
- adipocytes
- sod2
- steatosis
- caspase-3
- nafld
-
cardioprotective
-
foxo3a
-
senescence-associated
-
aging-related
-
mir-34a
-
hyperacetylation
-
anti-aging
- nampt
- tfam
- mnsod
-
p-ampk
-
monophosphate-activated
- coactivator-1
-
non-histone
- medicine
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Reaction Schemes
Synonyms
sirt1, sirt3, sirtuin, sirt2, sirtuin 1, sirtuin 3, sir2p, silent information regulator 2, sir2alpha, nad-dependent histone deacetylase, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
CobB
Hst1
HST2
NAD+-dependent protein deacetylase
-
-
-
-
NAD-dependent protein deacetylase
protein lysine deacetylase
silent information regulator 2
Sir2
SIR2-Af1
Sir2-Af2
SIRT1
SIRT2
SIRT3
sirtuin
sirtuin 1
sirtuin 3
protein lysine deacetylase
-
-
-
-
Sir2
-
-
-
-
SIRT1
Q96EB6
-
SIRT2
-
SIRT3
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
[protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[protein]-N6-acetyl-L-lysine + NAD+ = [protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
(1a)
-
-
-
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
(1b)
-
-
-
[protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
overall reaction
-
-
-
[protein]-N6-acetyl-L-lysine + NAD+ + H2O = [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
broad specificity with respect to chain length of the acyl chain
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SYSTEMATIC NAME
IUBMB Comments
[protein]-N6-acetyl-L-lysine:NAD+ N-acetyltransferase (NAD+-hydrolysing; 2''-O-acetyl-ADP-D-ribose-forming)
The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins. Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2 KKGQSTSRHKKAcLMFKTEG + 2 NAD+ + 2 H2O
KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + 3''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
acetyl-CoA + [protein]-L-lysine
CoA + [protein]-N6-acetyl-L-lysine
-
-
-
?
acetyl-cytochrome c + NAD+ + H2O
?
-
the enzyme does not deacetylate native acetyl-cytochrome c but does deacetylate the heat-denatured substrate
-
-
?
AGG(AcK)GG(AcK)GMG(AcK)VGA(AcK)RHSC + NAD+ + H2O
AGG(AcK)GG(AcK)GMG(AcK)VGAKRHSC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
tetraacetylated histone-H4 N-terminal tail peptide
-
-
?
ARTKQTAR(AcK)STGG(AcK)APRKQLC + NAD+ + H2O
ARTKQTARKSTGGKAPRKQLC + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
diacetyl ated histone-H3 N-terminal tail peptide
-
-
?
HLKSKKGQSTSRHK(K-Ac)LMFK + NAD+ + H2O
HLKSKKGQSTSRHKKLMFK + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
p53A peptide
-
-
?
hyperacetylated histone-DNA complex + NAD+ + H2O
deacetylated nuclease-resistant histone-DNA complex + ?
-
-
-
?
K382azaKAc-containing p53 peptide + NAD+ + H2O
K382azaK-containing p53 peptide + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
K382KAc-containing p53 peptide + NAD+ + H2O
K382K-containing p53 peptide + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
KSTGGAcKAPRKQ + NAD+ + H2O
KSTGGKAPRKQ + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
NAD+ + L-Arg-L-His-L-Lys-L-Lys(epsilon-acetyl)-7-amido-4-methylcoumarin
nicotinamide + ?
-
-
-
-
?
NAD+ + N2-benzyloxycarbonyl-N6-succinyl-L-lysine-7-amido-4-methylcoumarin
nicotinamide + N2-benzyloxycarbonyl-L-lysine-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP ribose
i.e. 3-[(5-[[(benzyloxy)carbonyl]amino]-5-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]pentyl)carbamoyl]-propanoic acid
-
-
?
NAD+ + N2-benzyloxycarbonyl-N6-succinyl-L-lysine-7-amido-4-methylcoumarin
nicotinamide + N2-benzyloxycarbonyl-L-lysine-7-amido-4-methylcoumarin + 2'-O-succinyl-ADP-ribose
i.e. 3-[(5-[[(benzyloxy)carbonyl]amino]-5-[(4-methyl-2-oxo-2H-chromen-7-yl)carbamoyl]pentyl)carbamoyl]-propanoic acid
-
-
?
NAD+ + QTAR(N6-acetyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-acetyl-ADP-ribose
acetylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-myristoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-myristoyl-ADP-ribose
myristoylated histone H3 peptide, about 45% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-palmitoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-palmitoyl-ADP-ribose
myristoylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-succinyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-succinyl-ADP-ribose
succinylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
-
-
?
NAD+ + TRSG(N6-acetyl)KVMR
nicotinamide + TRSGKVMR + 2'-O-acetyl-ADP-ribose
peptide based on an acetyl-CoA synthetase 2 acetylation site
-
-
?
NAD+ + TRSG(N6-acetyl)KVMRRLLR
nicotinamide + TRSGKVMRRLLR + 2'-O-acetyl-ADP-ribose
Q96EB6, Q9NTG7
acetylated substrate peptide based on the sequence of acetyl-coenzyme A synthetase 2
-
-
?
NAD+ + [alpha-tubulin peptide]-N6-acetyl-L-lysine
nicotinamide + [alpha-tubulin peptide]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acetyl-L-lysine40
nicotinamide + [alpha-tubulin]-L-lysine40 + 2'-O-acetyl-ADP ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
NAD+ + [BHJH-TM1 protein]-N6-myristoyl-L-lysine
nicotinamide + [BHJH-TM1 protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
NAD+ + [chicken erythrocyte histone]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP ribose
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
NAD+ + [Fluor de Lys protein]-N6-acyl-L-lysine
nicotinamide + [Fluor de Lys protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
-
?
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine
nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [glutamate oxaloacetate transaminase 2]-N6-acetyl-L-lysine
nicotinamide + [glutamate oxaloacetate transaminase 2]-L-lysine + 2'-O-acyl-ADP-ribose
isoform SIRT3 is the major deacetylase of glutamate oxaloacetate transaminase 2
-
-
?
NAD+ + [heat shock protein 10]-N6-acetyl-L-lysine56
nicotinamide + [heat shock protein 10]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H2B]-N6-acetyl-L-lysine12
nicotinamide + [histone H2B]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H2B]-N6-myristoyl-L-lysine12
nicotinamide + [histone H2B]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
NAD+ + [histone H3]-N6-myristoyl-L-lysine9
nicotinamide + [histone H3]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [histone H4]-N6-acetyl-L-lysine16
nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
NAD+ + [histone H4]-N6-acetyl-L-lysine8
nicotinamide + [histone H4]-L-lysine8 + 2'-O-acetyl-ADP-ribose
deacetylated at high concentrations of enzyme
-
-
?
NAD+ + [histone H4]-N6-myristoyl-L-lysine16
nicotinamide + [histone H4]-L-lysine + 2'-O-myristoyl-ADP-ribose
-
-
-
?
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [isocitrate dehydrogenase 2]-N6-acetyl-L-lysine413
nicotinamide + [isocitrate dehydrogenase 2]-L-lysine413 + 2'-O-acetyl-ADP-ribose
NAD+ + [nuclear receptor LXRalpha]-N6-acetyl-L-lysine432
nicotinamide + [nuclear receptor LXRalpha]-L-lysine432 + 2'-O-acetyl-ADP ribose
Q96EB6
-
-
-
?
NAD+ + [nuclear receptor LXRbeta]-N6-acetyl-L-lysine433
nicotinamide + [nuclear receptor LXRbeta]-L-lysine433 + 2'-O-acetyl-ADP ribose
Q96EB6
-
-
-
?
NAD+ + [nuclear receptor LXR]-N6-acetyl-L-lysine
nicotinamide + [nuclear receptor LXR]-L-lysine + 2'-O-acetyl-ADP ribose
Q96EB6
SIRT1 positively regulates liver X receptors (LXRs) by deacetylation at lysine. Deacetylation of liver X receptors (LXRs) by SIRT1 may be a mechanism that affects atherosclerosis and other agingassociated diseases
-
-
?
NAD+ + [p53 protein]-N6-acetyl-L-lysine
nicotinamide + [p53 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [p53 protein]-N6-acetyl-L-lysine382
nicotinamide + [p53 protein]-L-lysine382 + 2'-O-acetyl-ADP ribose
NAD+ + [PER2 protein]-N6-acetyl-L-lysine
nicotinamide + [PER2 protein]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [protein]-N6-acetyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [protein]-N6-acyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-acyl-ADP-ribose
NAD+ + [protein]-N6-myristoyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-myristoyl-ADP-ribose
demyristoylase activity of SIRT2 is 5fold more efficient than its deacetylase activity
-
-
?
NAD+ + [protein]-N6-succinyl-L-lysine
nicotinamide + [protein]-L-lysine + 2'-O-succinyl-ADP-ribose
-
-
-
?
NAD+ + [SREBP-1c]-N6-acetyl-L-lysine
nicotinamide + [SREBP-1c]-L-lysine + 2'-O-acetyl-ADP ribose
NAD+ + [thymine DNA glycosylase]-N6-acetyl-L-lysine
nicotinamide + [thymine DNA glycosylase]-L-lysine + 2'-O-acetyl-ADP-ribose
NAD+ + [very long-chain acyl-CoA dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [very long-chain acyl-CoA dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
[Acs protein]-N6-acetyl-L-lysine609 + NAD+ + H2O
[Acs protein]-L-lysine609 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[Alba protein]-N6-acetyl-L-lysine16 + NAD+ + H2O
[Alba protein]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[alpha-tubulin]-N6-acetyl-L-lysine40 + NAD+ + H2O
[alpha-tubulin]-L-lysine40 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[bovine serum albumin]-N6-acetyl-L-lysine + NAD+ + H2O
[bovine serum albumin]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
[histone H2B]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H2B]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
[histone H2B]-N6-acetyl-L-lysine20 + NAD+ + H2O
[histone H2B]-L-lysine20 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H2B]-N6-acetyl-L-lysine5 + NAD+ + H2O
[histone H2B]-L-lysine5 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H2]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H2]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
?
[histone H3]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H3]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[histone H3]-N6-acetyl-L-lysine14 + NAD+ + H2O
[histone H3]-L-lysine14 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H3]-N6-acetyl-L-lysine18 + NAD+ + H2O
[histone H3]-L-lysine18 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H3]-N6-acetyl-L-lysine23 + NAD+ + H2O
[histone H3]-L-lysine23 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H3]-N6-acetyl-L-lysine9 + NAD+ + H2O
[histone H3]-L-lysine9 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[histone H3]-N6-butyryl-L-lysine9 + NAD+ + H2O
[histone H3]-L-lysine9 + 2''-O-butyryl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H3]-N6-myristoyl-L-lysine9 + NAD+ + H2O
[histone H3]-L-lysine9 + 2''-O-myristoyl-ADP-D-ribose + nicotinamide
best substrate
-
-
?
[histone H3]-N6-octanoyl-L-lysine9 + NAD+ + H2O
[histone H3]-L-lysine9 + 2''-O-octanoyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H4]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[histone H4]-N6-acetyl-L-lysine12 + NAD+ + H2O
[histone H4]-L-lysine12 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H4]-N6-acetyl-L-lysine16 + NAD+ + H2O
[histone H4]-L-lysine16 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[histone H4]-N6-acetyl-L-lysine5 + NAD+ + H2O
[histone H4]-L-lysine5 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[histone H4]-N6-acetyl-L-lysine8 + NAD+ + H2O
[histone H4]-L-lysine8 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
weak activity
-
-
?
[HU protein]-N6-acetyl-L-lysine + NAD+ + H2O
[HU protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
overall reaction
-
-
?
[p53 peptide]-N6-acetyl-L-lysine382 + NAD+ + H2O
[p53 peptide]-L-lysine382 + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
?
[peptide p300]-N6-acetyl-L-lysine + NAD+ + H2O
[histone H4]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
peptide p300 with the sequence ERSTEL(K-Ac)TEI(K-Ac)EEEDQPSTS. The enzyme predominantly deacetylates at K1040 of full length peptide p300
-
-
?
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-N6-acetyl-L-lysine + NAD+
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + nicotinamide
[protein]-N6-acetyl-L-lysine + NAD+ + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
[protein]-N6-[1,1-(5-adenosylyl-alpha-D-ribose-1,2-di-O-yl)ethyl]-L-lysine + H2O
[protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
r
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
r
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
KKGQSTSRHKKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
-
-
-
r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
-
-
-
r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
-
-
-
r
KKGQSTSRHKLMFKTEG + 2''-O-acetyl-ADP-D-ribose + nicotinamide
KKGQSTSRHKKAcLMFKTEG + NAD+ + H2O
-
-
-
-
r
KSTGGK(Ac)APRKQ + beta-2'-deoxy-2'-fluororibo-NAD+ + H2O
?
-
the rates with beta-2'-deoxy-2'-fluororibo-NAD+ are about 1200fold slower than the exchange rates determined with NAD+ under similar conditions
-
-
?
KSTGGK(Ac)APRKQ + beta-2'-deoxy-2'-fluororibo-NAD+ + H2O
?
-
the rates with beta-2'-deoxy-2'-fluororibo-NAD+ are about 200fold slower than the exchange rates determined with NAD+ under similar conditions
-
-
?
KSTGGK(Ac)APRKQ + NAD+ + H2O
KSTGGKAPRKQ + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
an 11-mer histone H3 peptide
-
-
?
KSTGGK(Ac)APRKQ + NAD+ + H2O
KSTGGKAPRKQ + 2''-O-acetyl-ADP-D-ribose + nicotinamide
-
an 11-mer histone H3 peptide
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-butyryl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-butyryl-ADP-ribose
butyrylated histone H3 peptide, about 5% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-crotonyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
crotonylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-crotonyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-crotonyl-ADP-ribose
crotonylated histone H3 peptide, about 30% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 50% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
decanoylated histone H3 peptide, about 80% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
myristoylated histone H3 peptide, about 50% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-decanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-decanoyl-ADP-ribose
myristoylated histone H3 peptide, about 65% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 30% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + QTAR(N6-dodecanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-dodecanoyl-ADP-ribose
dodecanoylated histone H3 peptide, about 65% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide, about 20% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-hexanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-hexanoyl-ADP-ribose
hexanoylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide, about 35% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-octanoyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-octanoyl-ADP-ribose
octanoylated histone H3 peptide, about 55% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 10% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 40% compared to the activity with the acetylated peptide
-
-
?
NAD+ + QTAR(N6-propionyl)KSTGG
nicotinamide + QTARKSTGG + 2'-O-propionyl-ADP-ribose
propionylated histone H3 peptide, about 60% compared to the activity with the acetylated or hexanoylated peptide
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
?
NAD+ + [alpha-tubulin]-N6-acyl-L-lysine
nicotinamide + [alpha-tubulin]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
-
?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [BMAL1 protein]-N6-acyl-L-lysine
nicotinamide + [BMAL1 protein]-L-lysine + 2'-O-acyl-ADP-ribose
-
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
-
-
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
SIRT1 modulates DNA repair activity, which can be regulated by the acetylation status of repair protein Ku70 following DNA damage
-
-
?
NAD+ + [DNA repair factor Ku70]-N6-acetyl-L-lysine382
nicotinamide + [DNA repair factor Ku70]-L-lysine382 + 2'-O-acetyl-ADP-ribose
Q96EB6
-
-
-
?
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine
nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose
Q96EB6
Fluor de Lys is a fluorogenic, acetylated peptide substrate for human sirtuin 1, based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac)), a site of regulatory acetylation by the p300 and CBP acetyltransferases
-
-
?
NAD+ + [Fluor de Lys]-N6-acetyl-L-lysine
nicotinamide + [Fluor de Lys]-L-lysine + 2'-O-acetyl-ADP-ribose
Q923E4
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [glutamate dehydrogenase]-N6-acetyl-L-lysine
nicotinamide + [glutamate dehydrogenase]-L-lysine + 2'-O-acetyl-ADP-ribose
Sirt3 can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
-
-
-
?
NAD+ + [histone H3]-N6-acetyl-L-lysine9
nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose