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Literature summary for 2.3.1.286 extracted from

  • Vaquero, A.; Scher, M.B.; Lee, D.H.; Sutton, A.; Cheng, H.L.; Alt, F.W.; Serrano, L.; Sternglanz, R.; Reinberg, D.
    SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis (2006), Genes Dev., 20, 1256-1261.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.1.286

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm the enzyme is cytoplasmic during most of the cell cycle except in the G2/M transition and in mitosis Homo sapiens 5737
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nucleus in the G2/M transition and in mitosis the enzyme is localized in association with chromatin Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + [histone H4]-N6-acetyl-L-lysine16 Homo sapiens the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8IXJ6
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + [histone H3]-N6-acetyl-L-lysine9 deacetylated at high concentrations of enzyme Homo sapiens nicotinamide + [histone H3]-L-lysine9 + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine16 the deacetylation of [histone H4]-N6-acetyl-L-lysine16 may be pivotal to the formation of condensed chromatin Homo sapiens nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine16 strong preference for histone H4K16Ac in their deacetylation activity in vitro and in vivo Homo sapiens nicotinamide + [histone H4]-L-lysine16 + 2'-O-acetyl-ADP-ribose
-
 ?
NAD+ + [histone H4]-N6-acetyl-L-lysine8 deacetylated at high concentrations of enzyme Homo sapiens nicotinamide + [histone H4]-L-lysine8 + 2'-O-acetyl-ADP-ribose
-
 ?

Synonyms

Synonyms Comment Organism
SIRT2
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the deacetylation of [histone H4]-N6-acetyl-L-lysine16 by Sirt2 may be pivotal to the formation of condensed chromatin Homo sapiens