EC Number   |
Localization |
GeneOntology No. |
Reference  |
|---|
   3.4.17.23 | membrane |
enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture |
GO:0016020 AmiGO QuickGO |
658455 |
| 3.4.17.23 | more |
transmembrane domain |
- |
658963 |
| 3.4.17.23 | plasma membrane |
evenly distributed to detergent-soluble regions of the plasma membrane in non-polarized CHO cells, in polarized Madin-Darby canine kidney epithelial cells ACE is localized predominantly to the apical surface (92%) where it is proteolytically cleaved within the ectodomain to release a soluble form, recombinantly expressed enzymes |
GO:0005886 AmiGO QuickGO |
669404 |
| 3.4.17.23 | membrane |
transmembrane enzyme |
GO:0016020 AmiGO QuickGO |
678102 |
| 3.4.17.23 | membrane |
ACE2 also undergoes phorbol-12-myristate-13-acetate-inducible ectodomain shedding from the membrane |
GO:0016020 AmiGO QuickGO |
679705 |
| 3.4.17.23 | membrane |
- |
GO:0016020 AmiGO QuickGO |
658459, 659147, 679300, 679706, 679708, 680388, 710171 |
| 3.4.17.23 | plasma membrane |
the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu |
GO:0005886 AmiGO QuickGO |
679876 |
| 3.4.17.23 | membrane |
integral membrane protein |
GO:0016020 AmiGO QuickGO |
692972 |
| 3.4.17.23 | cytoplasm |
ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 |
GO:0005737 AmiGO QuickGO |
694170 |
| 3.4.17.23 | membrane |
ACE2 exists as bothmembrane bound and soluble forms, the latter being generated by proteolytic cleavage of the ectodomain by the tumor necrosis factor convertase ADAM17 |
GO:0016020 AmiGO QuickGO |
694170 |
