Application | Comment | Organism |
---|---|---|
medicine | ACE2 is a functional receptor for the causative agent of severe acute repiratory syndrome, the SARS coronavirus, ACE2 also plays a role in the development of liver fibrosis and subsequent cirrhosis | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid | MLN-4760 | Homo sapiens | |
DX600 | - |
Homo sapiens | |
additional information | not inhibited by captopri and lisinopril | Homo sapiens | |
Pro-Phe | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | transmembrane enzyme | Mus musculus | 16020 | - |
membrane | transmembrane enzyme | Homo sapiens | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | dependent | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
27000 | - |
SDS-PAGE | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine | a transmembrane glycoprotein with an extracellular catalytic domain. ACE2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colon | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Mus musculus | - |
kidney | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(des-Arg9)-bradykinin + H2O | - |
Homo sapiens | ? | - |
? | |
angiotensin I + H2O | poor affinity | Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin II + H2O | efficient cleavage | Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
apelin-13 + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
ACE2 homologue | - |
Mus musculus |
angiotensin converting enzyme 2 | functions as a carboxypeptidase | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000044 | - |
(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid | - |
Homo sapiens |