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Literature summary for 3.4.17.23 extracted from

  • Lambert, D.W.; Hooper, N.M.; Turner, A.J.
    Angiotensin-converting enzyme 2 and new insights into the renin-angiotensin system (2008), Biochem. Pharmacol., 75, 781-786.
    View publication on PubMed

Application

Application Comment Organism
medicine ACE2 is a functional receptor for the causative agent of severe acute repiratory syndrome, the SARS coronavirus, ACE2 also plays a role in the development of liver fibrosis and subsequent cirrhosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid MLN-4760 Homo sapiens
DX600
-
Homo sapiens
additional information not inhibited by captopri and lisinopril Homo sapiens
Pro-Phe
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane transmembrane enzyme Mus musculus 16020
-
membrane transmembrane enzyme Homo sapiens 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ dependent Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
27000
-
SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
angiotensin II + H2O = angiotensin-(1-7) + L-phenylalanine a transmembrane glycoprotein with an extracellular catalytic domain. ACE2 functions as a carboxypeptidase, cleaving a single C-terminal residue from a distinct range of substrates Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Mus musculus
-
kidney
-
Homo sapiens
-
lung
-
Homo sapiens
-
testis
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(des-Arg9)-bradykinin + H2O
-
Homo sapiens ?
-
?
angiotensin I + H2O poor affinity Homo sapiens angiotensin-(1-9) + Leu
-
?
angiotensin II + H2O efficient cleavage Homo sapiens angiotensin-(1-7) + Phe
-
?
apelin-13 + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ACE2
-
Homo sapiens
ACE2 homologue
-
Mus musculus
angiotensin converting enzyme 2 functions as a carboxypeptidase Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000044
-
(S,S)-2-[1-carboxy-2-[3-(3,5-dichlorobenzyl)-3H-inidazol-4-yl]-ethylamino]-4-methylpentanoic acid
-
Homo sapiens