Cloned (Comment) | Organism |
---|---|
expressed in HEK-ACE2 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | GM6001 does not have any effect on the activity of ACE2 and little effect on basal shedding of ACE2 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu | Homo sapiens | 5886 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(7-methoxycoumarin-4-yl)-acetyl-APK(2,4-dinitrophenyl) + H2O | - |
Homo sapiens | (7-methoxycoumarin-4-yl)-acetyl-AP + N6-(2,4-dinitrophenyl)-L-Lys | - |
? | |
angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
angiotensin II + H2O | - |
Homo sapiens | angiotensin-(1-7) + Phe | - |
? | |
additional information | the ACE2 ectodomain can be cleaved from the cell membrane and released into the extracellular milieu by stimulation of phorbol esters and ADAM17, calmodulin inhibits shedding of the ACE2 ectodomain from the membrane | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
ACE2 | - |
Homo sapiens |
angiotensin-converting enzyme-2 | - |
Homo sapiens |