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EC Number
Inhibitors
Commentary
Structure
5.4.3.8
cycloserine
20 mM, 43% inhibition
5.4.3.8
Aminooxyacetate
20 mM, 57% inhibition
5.4.3.8
D-penicillamine
20 mM, 9% inhibition
5.4.3.8
more
5 mM EDTA has no effect on activity
5.4.3.8
pyridoxal 5'-phosphate
5 mM, 47% inhibition
5.4.3.8
4,5-Dioxovalerate
competitive inhibition of pyridoxamine-phosphate form of the enzyme and mixed-type inhibition of the pyridoxal-phosphate form of the enzyme
5.4.3.8
gabaculine
complete inactivation by gabaculine when the enzyme is exposed to 5-amino-4-oxopentanoate, levulinate or 4,5-dioxovalerate in absence of glutamate 1-semialdehyde
5.4.3.8
more
no inhibition by 3-hydroxyglutamate
5.4.3.8
gabaculine
potent inhibitor
5.4.3.8
gabaculine
wild-type enzyme is inhibited, gabaculine-resistant mutant enzyme is not inhibited
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