Ligand cycloserine

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

Basic Ligand Information

Molecular Structure
Picture of cycloserine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C3H6N2O2
cycloserine
DYDCUQKUCUHJBH-UHFFFAOYSA-N
Synonyms:
4-amino-3-isoxazolidone, D-/L-cycloserine, DL-cycloserine, oxamycin

Roles as Enzyme Ligand

Activator in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
induction
-

Inhibitor in Enzyme-catalyzed Reactions (26 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
weak
-
strong, competitive
-
D-cycloserine and L-cycloserine are inhibitors, L-cycloserine is 14-fold more effective than D-cycloserine
-
soluble fraction
-
90% inhibition at 1 mM
-
D-isomer by a factor of 40 more inhibitory than L-isomer
-
weak inhibition
-
0.15 mM, 89% inhibition of aromatic aminotransferase from strain CB 6
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 42% inhibition
-
irreversible
-
20 mM, 43% inhibition
-

Enzyme Kinetic Parameters

IC50 Value (2 results)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.119
-
25°C, pH 8.0
86
-
pH 8.0, 42°C

References & Links

Links to other databases for cycloserine

ChEBI
PubChem
ChEBI
PubChem