Ligand 4,5-Dioxopentanoate

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Basic Ligand Information

Molecular Structure
Picture of 4,5-Dioxopentanoate (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H6O4
4,5-Dioxopentanoate
YHUFRVYVNKGICT-UHFFFAOYSA-N
Synonyms:
4,5-Dioxovalerate, 5-Oxolevulinic acid
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-alanine + 4,5-dioxopentanoate = 5-aminolevulinate + pyruvate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (21 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-glutamate + 4,5-dioxopentanoate = 5-aminolevulinate + 2-oxoglutarate
show the reaction diagram
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glutathione + 4,5-dioxovalerate = ?
show the reaction diagram
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4,5-Dioxovalerate = 5-Amino-4-oxopentanoate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
5-aminolevulinic acid + pyruvate = 5-oxolevulinic acid + L-alanine
show the reaction diagram
-
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition of pyridoxamine-phosphate form of the enzyme and mixed-type inhibition of the pyridoxal-phosphate form of the enzyme
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3D Structure of Enzyme-Ligand-Complex (PDB) (1 result)

EC NUMBER
ENZYME 3D STRUCTURE

Enzyme Kinetic Parameters

KM Value (18 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.84
-
pH 8.0, 35C
1.4
-
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References & Links

Links to other databases for 4,5-Dioxopentanoate

ChEBI
PubChem
ChEBI
PubChem