Ligand D-penicillamine

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Basic Ligand Information

Molecular Structure
Picture of D-penicillamine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C5H11NO2S
D-penicillamine
VVNCNSJFMMFHPL-VKHMYHEASA-N
Synonyms:
D-(-)-penicillamine

Roles as Enzyme Ligand

Substrate in Enzyme-catalyzed Reactions (1 result)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
D-penicillamine + O2 = ? + H2O
show the reaction diagram
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Activator in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
D-penicillamine achieves 128.3% of the rate of cyanide production of the control in the LPO/H2O2/acetonitrile system
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addition of D-penicillamine significantly enhances the rate of chloroacetonitrile oxidation and cyanide release by the myeloperoxidase/H2O2/Cl- system (17.2% increase at 5 mM)
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Inhibitor in Enzyme-catalyzed Reactions (24 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
L-enantiomer not as effective
-
1 mM, 73% inhibition
-
0.1 mM, inhibits activity with pyridoxal, but not with pyridoxamine as substrate, 20% inhibition
-
40.5% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine
-
32.4% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine
-
20.2% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine
-
10 mg/l, 43% inhibition
-
competitive
-
1 mM, 87% inhibition
-
1 mM, 79% inhibition
-
88% inhibition at 1 mM
-
20 mM, 9% inhibition
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Enzyme Kinetic Parameters

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.057
-
pH 8.0, 37°C
1.2
-
zinc carboxypeptidase A

IC50 Value (1 result)

EC NUMBER
IC50 VALUE
IC50 VALUE MAXIMUM
COMMENTARY
LITERATURE
0.05
-
pH not specified in the publication, temperature not specified in the publication

References & Links

Links to other databases for D-penicillamine

ChEBI
PubChem
ChEBI
PubChem