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EC Number
Inhibitors
Commentary
Structure
3.5.4.16
8-ethoxycarbonyl-7-deazaguanine
78% inhibition at 2.9 mM
3.5.4.16
8-methyl-7-deazaguanine
94% inhibition at 2.9 mM
3.5.4.16
8-oxo-dGTP
competitive inhibition
3.5.4.16
8-oxo-GTP
competitive inhibition, binds tightly to the enzyme with higher affinity than GTP, structure and binding network, overview
3.5.4.16
8-oxo-GTP
competitive inhibitor
3.5.4.16
8-oxo-GTP
competitive inhibitor. The inhibitor interacts with a conserved active site Cys149, and this residue is S-nitrosylated. Ki/Km: 0.022
3.5.4.16
8-trifluoromethyl-7-deazaguanine
17% inhibition at 2.9 mM
3.5.4.16
ADP
competitive inhibitor
3.5.4.16
Al3+
-
3.5.4.16
ascorbate
-
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