Any feedback?
No. of entries
Information on EC 3.5.4.16 - GTP cyclohydrolase I
for references in articles please use BRENDA:EC3.5.4.16
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
EC Tree 3 Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.16 GTP cyclohydrolase I
IUBMB Comments
The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 4.2.3.12 (6-pyruvoyltetrahydropterin synthase) .
The enzyme appears in viruses and cellular organisms
- 3.5.4.16
- tetrahydrobiopterin
- bh4
- endothelial
- dystonia
- hydroxylase
-
dopa-responsive
- dopamine
- sepiapterin
- biopterin
- parkinsonism
- pterins
- pteridine
- catecholamine
- dihydrofolate
- serotonin
-
segawa
- interferon-gamma
-
neurotransmitter
- 2,4-diamino-6-hydroxypyrimidine
- folate
- levodopa
- l-dopa
- ptp
- dihydropteridine
-
dopaminergic
-
diurnal
-
nigrostriatal
-
endothelium-dependent
- striatum
- dahp
- phenylketonuria
- hyperphenylalaninemia
-
cytokine-stimulated
- nutrition
- dihydropteroate
-
ido
- n-acetylserotonin
-
6r-l-erythro-5,6,7,8-tetrahydrobiopterin
- 7,8-dihydrobiopterin
- 6-pyruvoyl-tetrahydropterin
- dihydrobiopterin
- molecular biology
- indoleamine
- tetrahydropterin
- biotechnology
- medicine
-
catecholaminergic
showSynonyms
gtp cyclohydrolase i, gtpch, gtp cyclohydrolase, gtp cyclohydrolase 1, gtp-ch, gtp-cyclohydrolase i, gch-1, gtpch1, gtpch i, guanosine triphosphate cyclohydrolase i, more
topPlease wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
dihydroneopterin triphosphate synthase
-
-
-
-
FelE
folE
GCH
GCH1
GCHI
GCYH-IA
GCYH-IB
GTP 8-formylhydrolase
-
-
-
-
GTP cyclohydrolase
-
-
-
-
GTP cyclohydrolase 1
GTP cyclohydrolase I
GTP cyclohydrolase IB
GTP-CH-I
GTP-CH1
GTP-cyclohydrolase 1
GTP-cyclohydrolase I
GTPCH
GTPCH I
GTPCH1
GTPCHI
guanosine 5'-triphosphate-cyclohydrolase I
guanosine triphosphate 8-deformylase
-
-
-
-
guanosine triphosphate cyclohydrolase
-
-
-
-
guanosine triphosphate cyclohydrolase 1
guanosine triphosphate cyclohydrolase I
hydrolase, guanosine triphosphate cyclo-
-
-
-
-
MptA
Punch protein
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
-
-
-
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
the reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit, the recyclization may be non-enzymatic
-
-
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
allosteric regulation mechanism, active site structure
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
enzyme contains to thiol groups per active site, reaction mechanism
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
reaction and regulation mechanism, enzyme forms a stimulatory complex with the GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
reaction mechanism involving reaction intermediates
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
reaction mechanism, active site structure, GTP binding strcuture
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
reaction mechanism, six consecutive unimolecular reaction steps, the first of which being reversible
-
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit, the recyclization may be non-enzymic, reaction mechanism
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
substrate binding and reaction mechanism, transition state structure, modelling, overview
GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate
substrate binding and reaction mechanism, transition state structure, modelling, overview
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
amidine hydrolysis
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
MetaCyc
6-hydroxymethyl-dihydropterin diphosphate biosynthesis I, 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium), drosopterin and aurodrosopterin biosynthesis, erythro-tetrahydrobiopterin biosynthesis I, preQ0 biosynthesis, tetrahydromonapterin biosynthesis, threo-tetrahydrobiopterin biosynthesis
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SYSTEMATIC NAME
IUBMB Comments
GTP 7,8-8,9-dihydrolase
The reaction involves hydrolysis of two C-N bonds and isomerization of the pentose unit; the recyclization may be non-enzymic. This enzyme is involved in the de novo synthesis of tetrahydrobiopterin from GTP, with the other enzymes involved being EC 1.1.1.153 (sepiapterin reductase) and EC 4.2.3.12 (6-pyruvoyltetrahydropterin synthase) [3].
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
CAS REGISTRY NUMBER
COMMENTARY
37289-19-3
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-amino-5-formylamino-6-ribofuranosylamino-4(3H)-pyrimidinone triphosphate + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: substrate is the reaction intermediate of the overall reaction
Products: -
Products: -
?
beta,gamma-methyleneguanosine 5'-triphosphate + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
beta-gamma-methyleneguanosine 5'-triphosphate + H2O
beta-gamma-methylene-7,8-dihydroneopterin 3'-triphosphate + formate
-
Substrates: -
Products: -
Products: -
?
GDP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine diphosphate
GTP + H2O
2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone triphosphate + ?
-
Substrates: mutant H179N is not able to perform the whole reaction step
Products: -
Products: -
r
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
GTP + H2O
formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate
-
Substrates: -
Products: -
Products: -
?
guanosine 5'-[gamma-thio]triphosphate + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
-
Substrates: -
Products: -
Products: -
?
beta,gamma-methyleneguanosine 5'-triphosphate + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
-
Substrates: -
Products: -
Products: -
?
beta,gamma-methyleneguanosine 5'-triphosphate + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
-
Substrates: -
Products: -
Products: -
?
GDP + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
-
Substrates: -
Products: -
Products: -
?
GDP + H2O
dihydroneopterin 2',3'-cyclic phosphate + ?
-
Substrates: -
Products: -
Products: -
?
GDP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine diphosphate
Substrates: -
Products: i.e. dihydroneopterin 3'-triphosphate
Products: i.e. dihydroneopterin 3'-triphosphate
?
GDP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine diphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Substrates: -
Products: i.e. dihydroneopterin 3'-triphosphate
Products: i.e. dihydroneopterin 3'-triphosphate
?
GTP + H2O
dihydroneopterin triphosphate + formate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
dihydroneopterin triphosphate + formate
-
Substrates: first step in the biosynthesis of pteridine coenzymes, such as folic acid and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
dihydroneopterin triphosphate + formate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Q8S3C2
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Q8S3C2
Substrates: the enzyme mediates the first and committing step pf the pterin branch of the folate-synthesis pathway
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Q8S3C2
Substrates: the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: cyclization to dihydroneopterin triphosphate
Products: i.e. dihydroneopterin triphosphate
Products: i.e. dihydroneopterin triphosphate
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, important in the regulation of monoamine neurotransmitters such a s dopamine, norepinephrine, and serotonin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: substrate needs to be Mg2+-free
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme synthesizes the cofactor for the reaction of the phenylalanine hydroxylase
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: first committed step in the biosynthesis of tetrahydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: complex series of reaction steps
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: first committed step in the biosynthesis of tetrahydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: complex series of reaction steps
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme produces the cofactor tetrahydrobiopterin essential for activities of tyrosine hydroxylase and DOPA decarboxylase
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: rate-limiting step in the biosynthesis of tetrahydrobiopterin, a key factor necessary for nitric oxide synthase, and for the hydrolxylases that are involved in the production of catecholamines and serotonin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: estrogens play a regulatory role on the enzyme expression, the enzyme is involved in estrogen receptor interaction with cyclic AMP, role of receptor subtypes, overview
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme controls the biosynthesis pathway of tetrahydrobiopterin, which is a necessary cofactor for inducible nitric oxide synthase
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme is feedback regulated by the GTPCH feedback regulatory protein GFRP, overview
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Serratia indica
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: i.e. dihydroneopterin 3'-triphosphate
Products: i.e. dihydroneopterin 3'-triphosphate
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Substrates: -
Products: i.e. dihydroneopterin 3'-triphosphate
Products: i.e. dihydroneopterin 3'-triphosphate
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in biosynthesis of tetrahydrobiopterin, BH4
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
Serratia indica
-
Substrates: first step in pathway of pterins
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 7,8-dihydroneopterin 3'-triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + D-erythro-dihydroneopterin triphosphate
-
Substrates: first commited step in the biosynthesis of tetrahydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + D-erythro-dihydroneopterin triphosphate
-
Substrates: enzyme catalyzed opening of the imidazole ring of GTP, kinetically competent reaction intermediate is 2-amino-5-formylamino-6-ribosylamino-4(3H)-pyrimidinone
Products: -
Products: -
?
GTP + H2O
formate + D-erythro-dihydroneopterin triphosphate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + D-erythro-dihydroneopterin triphosphate
-
Substrates: first step of the biosynthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4
Products: -
Products: -
?
additional information
?
-
-
Substrates: GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase
Products: -
Products: -
?
additional information
?
-
-
Substrates: GTP cyclohydrolase I stimulates tyrosine hydroxylase activity by increasing the maximal velocity of the enzyme and fails to block the feedback inhibition of tyrosine hydroxylase by dopamine
Products: -
Products: -
?
additional information
?
-
-
Substrates: GCYH-I is not only the first enzyme of the tetrahydrofolate and tetrahydropterin pathways, but also the first enzyme of queuosine and archaeosine biosynthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: GCYH-I is not only the first enzyme of the tetrahydrofolate and tetrahydropterin pathways, but also the first enzyme of queuosine and archaeosine biosynthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: GTPCH I is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis
Products: -
Products: -
?
additional information
?
-
-
Substrates: catalyzes the first step in the biosynthesis of methanopterin
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity towards dGTP, ATP, GMP, ITP, fapy-GTP, or 7-methyl-GTP
Products: -
Products: -
?
additional information
?
-
-
Substrates: catalyzes the first step in the biosynthesis of methanopterin
Products: -
Products: -
?
additional information
?
-
-
Substrates: no activity towards dGTP, ATP, GMP, ITP, fapy-GTP, or 7-methyl-GTP
Products: -
Products: -
?
additional information
?
-
-
Substrates: GTPCH1 via tetrahydrobiopterin maintains normal blood pressure and endothelial function in vivo by preserving nitric oxide synthesis by endothelial NO synthase
Products: -
Products: -
?
additional information
?
-
-
Substrates: tetrahydrobiopterin production by GTPCH I occurs in close proximity to endothelial nitric oxide synthase
Products: -
Products: -
?
additional information
?
-
-
Substrates: isozyme GTPCHIa activity is involved in formation of the black markings on the larva during fourth ecdysis, pigmentation pathway overview
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme deficiency causes hyperphenylalaninemia with severe neurological disorders, the 3,4-dihydroxyphenylalanine, i.e. DOPA, responsive form of dystonia, and endothelial dysfunction, all by (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin depletion, the GTP cyclohydrolase I feedback regulatory protein GFRP binds to the enzyme and mediates the regulation of the enzyme by L-phenylalanine and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
Products: -
Products: -
?
additional information
?
-
-
Substrates: tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids, regulates its own synthesis through feedback inhibition of the enzyme mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme is complexed with the GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in a ratio of 1:2, complex formation is induced by phenylalanine and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin
Products: -
Products: -
?
additional information
?
-
-
Substrates: enzyme is complexed with the GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, in a ratio of 1:2, complex formation is induced by phenylalanine and (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin, i.e. BH4
Products: -
Products: -
?
additional information
?
-
-
Substrates: GCH-1 interacts with many signal transduction proteins such as receptors (NKG2-A/B-actvating NK receptor and latrophilin-2), kinase (Death-associated protein kinase 3), adaptors (Rho-GTPase-activating protein 7 and Rho-guanine nucleotide exchange factor 3) and transcriptional factors (ATF-6 alpha and interferon regulatory factor 1)
Products: -
Products: -
?
additional information
?
-
-
Substrates: GCH1 interacts with GCH1 interacts with GTP cyclohydrolase I feedback regulatory protein, GFRP, and very long-chain specific acyl-CoA dehydrogenase in the liver, tubulin beta-2A chain in the liver and brain, DnaJ homolog subfamily A member 1 and fatty aldehyde dehydrogenase in the liver, heart and kidney and eukaryotic translation initiation factor 3 subunit I in all organs tested, overview. GCH1 associates with mitochondrial proteins and interacts with VLCAD, a mitochondrial protein
Products: -
Products: -
?
additional information
?
-
-
Substrates: GCH1 interacts with GCH1 interacts with GTP cyclohydrolase I feedback regulatory protein, GFRP, and very long-chain specific acyl-CoA dehydrogenase in the liver, tubulin beta-2A chain in the liver and brain, DnaJ homolog subfamily A member 1 and fatty aldehyde dehydrogenase in the liver, heart and kidney and eukaryotic translation initiation factor 3 subunit I in all organs tested, overview. GCH1 associates with mitochondrial proteins and interacts with VLCAD, a mitochondrial protein
Products: -
Products: -
?
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)dihydropteridine triphosphate
GTP + H2O
dihydroneopterin triphosphate + formate
-
Substrates: first step in the biosynthesis of pteridine coenzymes, such as folic acid and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
dihydroneopterin triphosphate + formate
-
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Q8S3C2
Substrates: the enzyme mediates the first and committing step pf the pterin branch of the folate-synthesis pathway
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Q8S3C2
Substrates: the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: -
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: first step in the biosynthesis pathway leading to dihydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin, important in the regulation of monoamine neurotransmitters such a s dopamine, norepinephrine, and serotonin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: the enzyme is rate limiting in the tetrahydrobiopterin biosynthesis in adipose tissue, overview
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme synthesizes the cofactor for the reaction of the phenylalanine hydroxylase
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: first committed step in the biosynthesis of tetrahydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
Substrates: first committed step in the biosynthesis of tetrahydrofolate and tetrahydrobiopterin
Products: -
Products: -
?
GTP + H2O
formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
Substrates: the enzyme produces the cofactor tetrahydrobiopterin essential for activities of tyrosine hydroxylase and DOPA decarboxylase
Products: -
Products: -
?