Ligand 8-oxo-dGTP

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Basic Ligand Information

Molecular Structure
Picture of 8-oxo-dGTP (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C10H16N5O14P3
8-oxo-dGTP
BUZOGVVQWCXXDP-UOWFLXDJSA-N

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (9 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
8-oxo-dGTP + H2O = ?
show the reaction diagram
-
8-oxo-dGTP + H2O = ?
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
show the reaction diagram
-
8-oxo-dGTP + 2 H2O = 8-oxo-dGMP + 2 phosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = ?
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate
show the reaction diagram
-
8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
competitive inhibition
-

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (13 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE
0.58
-
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.96
-
pH 8.5, 37°C

KM Value (19 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.3
-
-
0.0986
-
in 50 mM Tris-HCl (pH 8.0), 5 mM MgCl2, 20 mM NaCl, 1 mM dithiothreitol, 0.2 mg/ml bovine serum albumin, at 37°C
0.43
-
pH 8.5, 37°C
0.05
-
pH 8.0, 37°C

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.00022
-
pH 8.5, 25°C, recombinant enzyme
0.0129
-
pH 8.0, 30°C, inhibition of 2-hydroxy-dATPase activity

References & Links

Links to other databases for 8-oxo-dGTP

ChEBI
PubChem
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PubChem