EC Number   |
Inhibitors |
Structure |
|---|
   2.7.3.2 | more |
lansoprazole at 0.003 mg/ml does not alter DNA integrity of human spermatozoa or activity of seminal creatine kinase after 1 h incubation period; there is no significant change in the activity of seminal creatine kinase by the effect of lansoprazole (0.003 mg/ml, 1 h incubation) |
 |
| 2.7.3.2 | more |
brain creatine kinase activity is lower on days 14 and 21 post-feeding in animals that receive aflatoxin B1-contaminated diet compared to the control group. The inhibition of brain enzyme activity appears to be mediated by the oxidation of lipids, proteins, and thiol group, as well as by a reduction in the antioxidant capacity |
|
| 2.7.3.2 | morphine |
0.00001-0.1 mM morphine significantly reduces recombinant enzymatic activity (27% inhibition at 0.001 mM, 80% inhibition at more than 0.05 mM); 27% inhibition at 0.001 m, 80% inhibition at more than 0.05 mM |
  |
| 2.7.3.2 | N-ethylmaleimide |
- |
|
| 2.7.3.2 | NaCl |
inactivation due to subunit dissociation, mechanism |
|
| 2.7.3.2 | NaCl |
enzyme activity slightly decreases with NaCl concentration up to 4 M, and a dramatic decline is observed above that value, with full inactivation at 4.5 M. In presence of guanidinium chloride, inactivation occurs much earlier. Inactivation by NaCl is due to dissociation of dimeric creatine kinase into its constitutive subunits, and upon monomerization, the protein becomes more susceptible to guanidinium denaturing effect; in the absence of added guanidine hydrochloride, MM-CK activity slightly decreases with NaCl concentration up to 4 M, but a dramatic decline is observed above that value, with full inactivation at 4.5 M. When guanidine is added, curves with similar shapes are obtained but NaCl concentrations needed to inactivate the enzyme are shifted towards lower values |
|
| 2.7.3.2 | nitrate |
mimics the phosphoryl group in the transition state |
|
| 2.7.3.2 | nitrite |
mimics the phosphoryl group in the transition state |
|
| 2.7.3.2 | NO2- |
- |
|
| 2.7.3.2 | NO3- |
inactivation at -17°C |
|
