EC Number   |
Inhibitors |
Structure |
|---|
   1.5.1.25 | 3,3',5'-L-triiodothyronine |
competitive inhibition |
   |
| 1.5.1.25 | 3,5,3'-L-triiodothyronine |
competitive inhibition |
|
| 1.5.1.25 | 3,5-diiodothyronine |
competitive inhibition |
|
| 1.5.1.25 | L-thyroxine |
competitive inhibition |
|
| 1.5.1.25 | L-tyrosine |
competitive inhibition |
|
| 1.5.1.25 | picolinate |
competitive inhibition, picolinate is a much poorer inhibitor than pyrrole-2-carboxylate because it does not possess a ring -NH and relies on a relatively weak ring interaction |
|
| 1.5.1.25 | pyrrole-2-carboxylate |
competitive inhibition, pyrrole-2-carboxylate is an effective inhibitor of ketimine reductase/CRYM mainly as a result of the -NH hydrogen bonding to an active site residue |
|
| 1.5.1.25 | more |
in silico docking of substrates and inhibitors using ketimine reductase/CRYM cyrstal structure, PDB ID 4BVA, overview |
|
| 1.5.1.25 | Triton X-100 |
irreversible inactivation |
|
| 1.5.1.25 | 3,5-diiodo-L-tyrosine |
low competitive inhibition |
|
