Ligand 3,5-diiodo-L-tyrosine

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Basic Ligand Information

Molecular Structure
Picture of 3,5-diiodo-L-tyrosine (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C9H9I2NO3
3,5-diiodo-L-tyrosine
NYPYHUZRZVSYKL-ZETCQYMHSA-N
Synonyms:
3,5-di-iodotyrosine, 3,5-diiodotyrosine, Diiodo-L-tyrosine, diiodotyrosine, L-diiodotyrosine
Pathway Source
Pathways

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
3,5-diiodo-L-tyrosine + NADPH + H+ = 3-iodo-L-tyrosine + NADP+ + I-
show the reaction diagram
-
3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3,5-diiodo-4-hydroxyphenylpyruvate + L-glutamate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE

Substrate in Enzyme-catalyzed Reactions (8 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
diiodotyrosine + H2O2 + I- = ?
show the reaction diagram
-
3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3-(3,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-
3,5-di-iodotyrosine + 2-oxoglutarate = 3,5-diiodophenylpyruvate + L-glutamate
show the reaction diagram
-
3,5-diiodo-L-tyrosine + 2-oxoglutarate = 3-(2,5-diiodo-4-hydroxyphenyl)-2-oxopropanoate + L-glutamate
show the reaction diagram
-

Product in Enzyme-catalyzed Reactions (7 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-L-phenylalanyl-L-diiodotyrosine + H2O = acetyl-L-phenylalanine + L-diiodotyrosine
show the reaction diagram
-
-
acetyl-Phe-L-diiodotyrosine + H2O = acetyl-L-phenylalanine + L-diiodotyrosine
show the reaction diagram
-

Inhibitor in Enzyme-catalyzed Reactions (4 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE
1 mM, 15% inhibition
-
pronounced substrate inhibition above 5 microM
-
low competitive inhibition
-

3D Structure of Enzyme-Ligand-Complex (PDB) (34 results)

Enzyme Kinetic Parameters

kcat Value (Turnover Number) (7 results)

EC NUMBER
TURNOVER NUMBER [1/S]
TURNOVER NUMBER MAXIMUM [1/S]
COMMENTARY
LITERATURE

KM Value (10 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
1.1
1.3
pH 6.2, 37°C
0.9
-
pH 7.8, 37°C

Ki Value (1 result)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.313
-
pH 7.2, 37°C

References & Links

Links to other databases for 3,5-diiodo-L-tyrosine

ChEBI
PubChem
ChEBI
PubChem