EC Number   |
Activating Compound |
Reference |
|---|
    4.1.1.9 | phosphate |
activates |
4845 |
| 4.1.1.9 | AMP-activated potein kinase |
AMP-activated potein kinase activates MCD by phosphorylation |
691964 |
| 4.1.1.9 | 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside |
AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A |
652024 |
| 4.1.1.9 | more |
gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase |
652024 |
| 4.1.1.9 | more |
high-fat feeding, fasting and streptozotocin-induced diabetes increase the plasma concentration of nonesterified fatty acids, with a concomitant increase in both heart and skeletal muscle MCD mRNA |
649300 |
| 4.1.1.9 | fenofibrate |
increases hepatic mRNA expression and MCD activity |
649775 |
| 4.1.1.9 | fatty acid |
increases MCD expression in heart and skeletal muscle |
649300 |
| 4.1.1.9 | iodoacetamide |
malonyl-decarboxylase activity is induced by treatment of fatty acid synthetase with iodoacetamide |
4848 |
| 4.1.1.9 | more |
MCD activity is elevated under conditions in which hepatic fatty acid oxidation is known to increase, such as streptozotocin-induced diabetes or following a 48 h fast, 2fold increase in expression in streptozotocin-diabetic rats compared with controls |
649690 |
| 4.1.1.9 | more |
peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression |
649775 |
