Activating Compound | Comment | Organism | Structure |
---|---|---|---|
fenofibrate | increases hepatic mRNA expression and MCD activity | Rattus norvegicus | |
additional information | peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression | Rattus norvegicus |
Cloned (Comment) | Organism |
---|---|
- |
Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | Rattus norvegicus | important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene | Acetyl-CoA + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
fenofibrate-fed Otsuka Long-Evans Tokushima fatty rats | - |
Purification (Comment) | Organism |
---|---|
partial, from liver | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
Malonyl-CoA | - |
Rattus norvegicus | Acetyl-CoA + CO2 | - |
? | |
Malonyl-CoA | important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene | Rattus norvegicus | Acetyl-CoA + CO2 | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Rattus norvegicus |