Literature summary for 4.1.1.9 extracted from

Saha, A.K.; Schwarsin, A.J.; Roduit, R.; Masse, F.; Kaushik, V.; Tornheim, K.; Prentki, M.; Ruderman, N.B.
Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (2000), J. Biol. Chem., 275, 24279-24283.

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Activating Compound

Activating Compound	Comment	Organism	Structure
5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside	AMP-activated protein kinase activator, 2fold activation of MCD in extensor digitorum longus, reversed by protein phosphatase A	Rattus norvegicus
additional information	gastrocnemius contraction activates MCD, reversed by protein phosphatase A or by omitting phosphatase inhibitors from assay mixture, increase of MCD activity after skeletal muscle contraction is likely due to its phosphorylation by AMP-activated protein kinase	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.119	-	malonyl-CoA	gastrocnemius after 5 min of contraction	Rattus norvegicus
0.19	-	malonyl-CoA	gastrocnemius, relaxed	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Malonyl-CoA	Rattus norvegicus	control of malonyl-CoA concentration	Acetyl-CoA + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	male Harlan Sprague-Dawley rats	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	activation of AMP-activated protein kinase during muscle contraction leads to phosphorylation of MCD and an increase in its activity	Rattus norvegicus

Purification (Commentary)

Purification (Comment)	Organism
partial	Rattus norvegicus

Source Tissue

Source Tissue	Comment	Organism	Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Rattus norvegicus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Malonyl-CoA	-	Rattus norvegicus	Acetyl-CoA + CO2	-	?
Malonyl-CoA	control of malonyl-CoA concentration	Rattus norvegicus	Acetyl-CoA + CO2	-	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	8	-	Rattus norvegicus

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Release 2023.1 (January 2023)