EC Number |
Activating Compound |
Reference |
---|
2.4.1.255 | UDP-N-acetyl-D-glucosamine |
- |
723564 |
2.4.1.255 | Ataxin-10 |
Atx-10 increases OGT activity 2fold |
674603 |
2.4.1.255 | more |
beginning 12 h after treatment, glucose deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mM) |
704458 |
2.4.1.255 | Ataxin-10 |
encoded by the SCA10 (spinocerebellar ataxia type 10) gene, interacts with O-GlcNAc transferase OGT in pancreatic beta cells |
657790 |
2.4.1.255 | more |
GPX1 activity is increased about 0.5fold by OGT |
702092 |
2.4.1.255 | D-glucose |
immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose |
701898 |
2.4.1.255 | hyperglycemia |
increases O-GlcNAc levels in pancreatic beta cells, which appears to interfere with beta-cell function |
657790 |
2.4.1.255 | dithiothreitol |
increases the activity of wild type OGT |
659497 |
2.4.1.255 | O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate |
inhibitor of O-GlcNAcase, increase of the level of O-GlcNAc modifications |
703439 |
2.4.1.255 | more |
insulin signaling stimulates tyrosine phosphorylation of OGT, increases its catalytic activity, affects OGT localization, and results in the O-GlcNAc modification of STAT3, a key kinase and transcription factor in 3T3-L1 adipocytes |
693100 |