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Information on EC 2.4.1.255 - protein O-GlcNAc transferase

for references in articles please use BRENDA:EC2.4.1.255

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IUBMB Comments

Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. EC 2.4.1.255 (protein O-GlcNAc transferase) transfers GlcNAc onto substrate proteins and EC 3.2.1.169 (protein O-GlcNAcase) cleaves GlcNAc from the modified proteins.

The enzyme appears in viruses and cellular organisms

Synonyms
o-linked n-acetylglucosamine transferase, ogt protein, o-glcnac protein, n-acetylglucosamine transferase, o-glcnac-transferase, human ogt, ncogt, secret agent, o-linked glcnac transferase, o-linked n-acetylglucosaminyltransferase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine
show the reaction diagram
The N-acetyl-D-glucosaminyl residue is transferred to threonine or serine hydroxy groups on the polypeptide.
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UDP-N-acetyl-alpha-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
MetaCyc
protein O-[N-acetyl]-glucosylation