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Literature summary for 2.4.1.255 extracted from

  • Whelan, S.A.; Lane, M.D.; Hart, G.W.
    Regulation of the O-linked beta-N-acetylglucosamine transferase by insulin signaling (2008), J. Biol. Chem., 283, 21411-21417.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
Insulin tyrosine phosphorylation of OGT increases significantly after a 10 min insulin treatment Mus musculus
additional information insulin signaling stimulates tyrosine phosphorylation of OGT, increases its catalytic activity, affects OGT localization, and results in the O-GlcNAc modification of STAT3, a key kinase and transcription factor in 3T3-L1 adipocytes Mus musculus
vanadate tyrosine phosphatase inhibitor sodium vanadate, treatment increases OGT activity. When insulin is added to cells preincubated with sodium vanadate, there is a further increase in OGT activity versus inhibitor alone Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
modified with both O-GlcNAc and tyrosine phosphorylation when overexpressed in insect cells Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus enzyme catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases ?
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme catalyzes the addition of O-linked beta-N-acetylglucosamine (O-GlcNAc) onto serine and threonine residues in response to stimuli or stress analogous to phosphorylation by Ser/Thr-kinases Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
Mus musculus
O-linked beta-N-acetylglucosamine transferase
-
Mus musculus
OGT
-
Mus musculus