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Literature summary for 2.4.1.255 extracted from

  • Akimoto, Y.; Kreppel, L.K.; Hirano, H.; Hart, G.W.
    Hyperglycemia and the O-GlcNAc transferase in rat aortic smooth muscle cells: elevated expression and altered patterns of O-GlcNAcylation (2001), Arch. Biochem. Biophys., 389, 166-175.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
D-glucose immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose Rattus norvegicus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
78000
-
1 * 78000 + 1 * 110000 Rattus norvegicus
110000
-
1 * 78000 + 1 * 110000 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus catalyses the O-linked attachment of single GlcNAc moieties to serine and threonine residues on many cytosolic or nuclear proteins ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P56558
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta distribution of OGTase in the aorta is examined by immunofluorescence microscopy Rattus norvegicus
-
aortic endothelial cell
-
Rattus norvegicus
-
aortic smooth muscle cell
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information catalyses the O-linked attachment of single GlcNAc moieties to serine and threonine residues on many cytosolic or nuclear proteins Rattus norvegicus ?
-
?
UDP-GlcNAc + YSDSPSTST
-
Rattus norvegicus UDP + GlcNAc-YSDSPSTST
-
?

Subunits

Subunits Comment Organism
heterodimer 1 * 78000 + 1 * 110000 Rattus norvegicus

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
Rattus norvegicus
OGTase
-
Rattus norvegicus
UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
20
-
assay at Rattus norvegicus