Activating Compound | Comment | Organism | Structure |
---|---|---|---|
D-glucose | immunoblot analysis of OGTase expression in RASM cells. The amount of the 78 kDa subunit is significantly increased in the high glucose, but no significant increase in the amount of the 110 kDa subunit is observed. OGTase expression and activity increased in the RASM cells cultured in the 20 mM glucose | Rattus norvegicus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
78000 | - |
1 * 78000 + 1 * 110000 | Rattus norvegicus |
110000 | - |
1 * 78000 + 1 * 110000 | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | catalyses the O-linked attachment of single GlcNAc moieties to serine and threonine residues on many cytosolic or nuclear proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P56558 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | distribution of OGTase in the aorta is examined by immunofluorescence microscopy | Rattus norvegicus | - |
aortic endothelial cell | - |
Rattus norvegicus | - |
aortic smooth muscle cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | catalyses the O-linked attachment of single GlcNAc moieties to serine and threonine residues on many cytosolic or nuclear proteins | Rattus norvegicus | ? | - |
? | |
UDP-GlcNAc + YSDSPSTST | - |
Rattus norvegicus | UDP + GlcNAc-YSDSPSTST | - |
? |
Subunits | Comment | Organism |
---|---|---|
heterodimer | 1 * 78000 + 1 * 110000 | Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Rattus norvegicus |
OGTase | - |
Rattus norvegicus |
UDP-GlcNAc: polypeptide O-N-acetylglucosaminyltransferase | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | - |
assay at | Rattus norvegicus |