EC Number   |
Activating Compound |
Reference |
|---|
    1.14.16.2 | endothelin-1 |
effects of long-term modulation at different concentrations, overview |
684367 |
| 1.14.16.2 | endothelin-2 |
effects of long-term modulation at different concentrations, overview |
684367 |
| 1.14.16.2 | estradiol-17beta |
activating at concetration below 0.5 mM |
673820 |
| 1.14.16.2 | estradiol-17beta |
biphasic effects on in vivo and in vitro enzyme activity and kinetics. Low concentrations (1 nM) stimulate, and high concentrations (1 mM) inhibit |
658785 |
| 1.14.16.2 | forskolin |
forskolin selectively increases the phosphorylation of tyrosine hydroxylase at Ser40 by 1.8fold without increasing total tyrosine hydroxylase protein levels |
700435 |
| 1.14.16.2 | forskolin |
i.e. 8-CPTcAMP, tyrosine hydroxylase protein level and activity rate are increased in MN9D cells in response to treatment with 8-CPTcAMP, mechanism, overview |
689074 |
| 1.14.16.2 | GTP cyclohydrolase I |
as concentrations of 5,6,7,8-tetrahydrobiopterin are increased (0.025 and 0.1 mM), the specific activity of tyrosine hydroxylase is stimulated in the presence of GTP cyclohydrolase I isoform C |
698830 |
| 1.14.16.2 | heparin |
0.1 mg/ml, activates |
438690, 438696 |
| 1.14.16.2 | heparin |
activates the enzyme in the crude extract, less effective with the purified enzyme |
438698 |
| 1.14.16.2 | Hsc70 |
Hsc70 physically and functionally interacts with TH to regulate the enzyme activity and synaptic vesicle targeting |
745347 |
