EC Number   |
Activating Compound |
Reference |
|---|
    1.1.1.41 | AMP |
allosteric activation, isocitrate binding is essential for binding of AMP to IDH1 subunits |
721650 |
| 1.1.1.41 | AMP |
allosteric activator, binding site at subunit IDH1 |
656118 |
| 1.1.1.41 | AMP |
four AMP binding sites located on subunit IDH2 |
721650 |
| 1.1.1.41 | ATP |
the enzyme can be activated by low concentrations of ATP. At high concentrations ATP is competitive with NAD+ for binding to the catalytic site |
762407 |
| 1.1.1.41 | citrate |
- |
760834, 761502, 762407, 762451 |
| 1.1.1.41 | citrate |
106.29% activity at 1 mM |
761311 |
| 1.1.1.41 | citrate |
110% activity at 2 mM |
760649 |
| 1.1.1.41 | citrate |
the alpha2betagamma heterotetramer and alphagamma heterodimer can be allosterically activated by citrate |
762437 |
| 1.1.1.41 | DTT |
- |
721650 |
| 1.1.1.41 | DTT |
decreases disulfide content of the enzyme, kinetics of enzyme mutants in presence or absence of DTT, overview |
721650 |
