Ontology explorer

Gene ontology

Change ontology: Version 2014-12-22

Term or Synonym: use AND (NOT) or OR

Definition: use AND (NOT) or OR

Id:

restrict to BRENDA links:

Localization

Enzyme

Details for pyrimidine dimer DNA N-glycosylase activity

Gene ontology ID

GO:0000704

Definition

Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site

References

1. GOC: elh
2. PMID 9224623

Legend

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

at least 1 tissue/ enzyme/ localization link in this branch

tissue/ enzyme/ localization link to BRENDA

Condensed Tree View

Gene ontology

molecular_function is a

catalytic activity is a

catalytic activity, acting on DNA is a

DNA N-glycosylase activity is a

oxidized base lesion DNA N-glycosylase activity is a

pyrimidine dimer DNA N-glycosylase activity is a

Tree view

Gene ontology

biological_process is a

cellular_component is a

molecular_function is a

binding

catalytic activity is a

catalytic activity, acting on a protein is a

catalytic activity, acting on DNA is a

5'-deoxyribose-5-phosphate lyase activity is a

deoxyribodipyrimidine endonucleosidase activity is a

DNA alpha-glucosyltransferase activity is a

DNA beta-glucosyltransferase activity is a

DNA N-glycosylase activity is a

alkylbase DNA N-glycosylase activity is a

deaminated base DNA N-glycosylase activity is a

mismatch base pair DNA N-glycosylase activity is a

oxidized base lesion DNA N-glycosylase activity is a

oxidized purine nucleobase lesion DNA N-glycosylase activity is a

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity is a

pyrimidine dimer DNA N-glycosylase activity is a

DNA nucleotidylexotransferase activity is a

DNA photolyase activity is a

DNA-(apurinic or apyrimidinic site) endonuclease activity is a

DNA-deoxyinosine glycosylase activity is a

DNA/RNA helicase activity is a

phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands is a

transposase activity is a

tyrosyl-DNA phosphodiesterase activity is a

catalytic activity, acting on RNA is a

cyclase activity is a

hydrolase activity is a

isomerase activity is a

ligase activity is a

lyase activity is a

peptidoglycan muralytic activity is a

transferase activity is a

molecular transducer activity is a

nutrient reservoir activity is a

protein tag is a

small molecule sensor activity is a

structural molecule activity is a

transcription regulator activity is a

transporter activity is a