Ontology explorer

Gene ontology

Change ontology: Version 2014-12-22

Term or Synonym: use AND (NOT) or OR

Definition: use AND (NOT) or OR

Id:

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Localization

Enzyme

Details for oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

Gene ontology ID

GO:0000703

Definition

Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site

Comment

Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.

Synonyms

1. bifunctional DNA glycosylase
2. DNA glycosylase/AP-lyase
3. DNA glycosylase/beta-lyase
4. endodeoxyribonuclease III
5. endonuclease III
6. endonuclease VIII activity
7. oxidized pyrimidine base lesion DNA N-glycosylase activity
8. pyrimidine-specific oxidized base lesion DNA N-glycosylase activity

References

1. GOC: elh
2. PMID 11554296
3. Reactome: R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase"
4. Reactome: R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase"
5. Reactome: R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase"

Legend

is an element of the parent element

is a part of the parent element

is related to the parent element

derives from the parent element

at least 1 tissue/ enzyme/ localization link in this branch

tissue/ enzyme/ localization link to BRENDA

Condensed Tree View

Gene ontology

molecular_function is a

catalytic activity is a

catalytic activity, acting on DNA is a

DNA N-glycosylase activity is a

oxidized base lesion DNA N-glycosylase activity is a

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity is a

Tree view

Gene ontology

biological_process is a

cellular_component is a

molecular_function is a

binding

catalytic activity is a

catalytic activity, acting on a protein is a

catalytic activity, acting on DNA is a

5'-deoxyribose-5-phosphate lyase activity is a

deoxyribodipyrimidine endonucleosidase activity is a

DNA alpha-glucosyltransferase activity is a

DNA beta-glucosyltransferase activity is a

DNA N-glycosylase activity is a

alkylbase DNA N-glycosylase activity is a

deaminated base DNA N-glycosylase activity is a

mismatch base pair DNA N-glycosylase activity is a

oxidized base lesion DNA N-glycosylase activity is a

oxidized purine nucleobase lesion DNA N-glycosylase activity is a

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity is a

pyrimidine dimer DNA N-glycosylase activity is a

DNA nucleotidylexotransferase activity is a

DNA photolyase activity is a

DNA-(apurinic or apyrimidinic site) endonuclease activity is a

DNA-deoxyinosine glycosylase activity is a

DNA/RNA helicase activity is a

phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands is a

transposase activity is a

tyrosyl-DNA phosphodiesterase activity is a

catalytic activity, acting on RNA is a

cyclase activity is a

hydrolase activity is a

isomerase activity is a

ligase activity is a

lyase activity is a

peptidoglycan muralytic activity is a

transferase activity is a

molecular transducer activity is a

nutrient reservoir activity is a

protein tag is a

small molecule sensor activity is a

structural molecule activity is a

transcription regulator activity is a

transporter activity is a