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Gene ontology
Version 2014-12-22
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Details for MAP kinase kinase kinase kinase activity
Gene ontology ID
GO:0008349
Definition
Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli
Synonyms
1. MAP4K activity
2. MAPKKKK
References
1. GOC: bf
2. PMID 11790549
3. Reactome: R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex"
4. Reactome: R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3"
Legend
is an element of the parent element
is a part of the parent element
is related to the parent element
derives from the parent element
// at least 1 tissue/ enzyme/ localization link in this branch
// tissue/ enzyme/ localization link to BRENDA
Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
positive regulation of biological process is a
positive regulation of cellular process is a
positive regulation of cell communication is a
positive regulation of signal transduction is a
positive regulation of intracellular signal transduction is a
positive regulation of MAPK cascade is a
positive regulation of MAP kinase activity is a
activation of MAPK activity is a
MAP kinase kinase activity part of
activation of MAPKK activity
MAP kinase kinase kinase activity part of
activation of MAPKKK activity
MAP kinase kinase kinase kinase activity part of
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
positive regulation of biological process is a
positive regulation by symbiont of entry into host is a
positive regulation of action potential is a
positive regulation of asexual reproduction is a
positive regulation of biomineralization is a
positive regulation of cellular process is a
positive regulation of actin filament severing is a
positive regulation of amino acid uptake involved in synaptic transmission is a
positive regulation of calcium ion transport into cytosol is a
positive regulation of cartilage condensation is a
positive regulation of catecholamine uptake involved in synaptic transmission is a
positive regulation of cell activation is a
positive regulation of cell adhesion molecule production is a
positive regulation of cell aging is a
positive regulation of cell communication is a
activation of prostate induction by androgen receptor signaling pathway is a
positive regulation of aggregation involved in sorocarp development is a
positive regulation of BMP secretion is a
positive regulation of c-di-GMP signaling is a
positive regulation of cell communication by chemical coupling is a
positive regulation of cell communication by electrical coupling is a
positive regulation of cellular response to amino acid starvation is a
positive regulation of cellular response to phosphate starvation is a
positive regulation of cytokine secretion is a
positive regulation of dopamine secretion is a
positive regulation of establishment of competence for transformation is a
positive regulation of hormone secretion is a
positive regulation of norepinephrine secretion is a
positive regulation of prostaglandin secretion is a
positive regulation of renin secretion into blood stream is a
positive regulation of retrograde trans-synaptic signaling by neuropeptide is a
positive regulation of serotonin secretion is a
positive regulation of signal transduction is a
induction by symbiont of host cAMP-mediated signal transduction is a
positive adaptation of signaling pathway is a
positive regulation by symbiont of host salicylic acid-mediated defense response is a
positive regulation of abscisic acid-activated signaling pathway is a
positive regulation of androgen receptor activity is a
positive regulation of anti-Mullerian hormone signaling pathway is a
positive regulation of antigen receptor-mediated signaling pathway is a
positive regulation of apolipoprotein A-I-mediated signaling pathway is a
positive regulation of apoptotic signaling pathway is a
positive regulation of auxin mediated signaling pathway is a
positive regulation of brain-derived neurotrophic factor receptor signaling pathway is a
positive regulation of brassinosteroid mediated signaling pathway is a
positive regulation of CD40 signaling pathway is a
positive regulation of chemorepellent activity is a
positive regulation of corticotropin-releasing hormone receptor activity is a
positive regulation of cytokine activity is a
positive regulation of cytokine-mediated signaling pathway is a
positive regulation of cytokinin-activated signaling pathway is a
positive regulation of dopamine receptor signaling pathway is a
positive regulation of endoplasmic reticulum unfolded protein response is a
positive regulation of ephrin receptor signaling pathway is a
positive regulation of ERBB signaling pathway is a
positive regulation of excitatory postsynaptic potential is a
positive regulation of Fas signaling pathway is a
positive regulation of Fc receptor mediated stimulatory signaling pathway is a
positive regulation of fibroblast growth factor receptor signaling pathway is a
positive regulation of G protein-coupled receptor signaling pathway is a
positive regulation of gibberellic acid mediated signaling pathway is a
positive regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation is a
positive regulation of glucocorticoid mediated signaling pathway is a
positive regulation of glucose mediated signaling pathway is a
positive regulation of glutamate receptor signaling pathway is a
positive regulation of growth hormone activity is a
positive regulation of growth hormone receptor signaling pathway is a
positive regulation of hepatocyte growth factor receptor signaling pathway is a
positive regulation of hypoxia-inducible factor-1alpha signaling pathway is a
positive regulation of inhibitory postsynaptic potential is a
positive regulation of insulin receptor signaling pathway is a
positive regulation of insulin-like growth factor receptor signaling pathway is a
positive regulation of integrin-mediated signaling pathway is a
positive regulation of intracellular signal transduction is a
positive regulation of calcium-mediated signaling is a
positive regulation of cAMP-mediated signaling is a
positive regulation of cGMP-mediated signaling is a
positive regulation of hippo signaling is a
positive regulation of I-kappaB kinase/NF-kappaB signaling is a
positive regulation of MAPK cascade is a
MAP-kinase scaffold activity part of
positive regulation of ERK1 and ERK2 cascade is a
positive regulation of ERK5 cascade is a
positive regulation of MAP kinase activity is a
activation of MAPK activity is a
activation of JUN kinase activity is a
activation of MAPK activity by adrenergic receptor signaling pathway is a
activation of MAPK activity involved in cell wall organization or biogenesis is a
activation of MAPK activity involved in conjugation with cellular fusion is a
activation of MAPK activity involved in osmosensory signaling pathway is a
MAP kinase kinase activity part of
activation of MAPKK activity
activation of MAPKK activity involved in cell wall organization or biogenesis is a
activation of MAPKK activity involved in conjugation with cellular fusion is a
activation of MAPKK activity involved in osmosensory signaling pathway is a
MAP kinase kinase kinase activity part of
activation of MAPKKK activity
activation of MAPKKK activity involved in cell wall organization or biogenesis is a
activation of MAPKKK activity involved in conjugation with cellular fusion is a
activation of MAPKKK activity involved in osmosensory signaling pathway is a
MAP kinase kinase kinase kinase activity part of
positive regulation of JUN kinase activity is a
positive regulation of MAPK cascade involved in axon regeneration is a
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway is a
positive regulation of pheromone response MAPK cascade is a
positive regulation of stress-activated MAPK cascade is a
positive regulation of MDA-5 signaling pathway is a
positive regulation of NIK/NF-kappaB signaling is a
positive regulation of nitric oxide mediated signal transduction is a
positive regulation of nucleotide-binding oligomerization domain containing signaling pathway is a
positive regulation of phosphatidylinositol 3-kinase signaling is a
positive regulation of phosphorelay signal transduction system is a
positive regulation of protein kinase A signaling is a
positive regulation of protein kinase B signaling is a
positive regulation of protein kinase C signaling is a
positive regulation of protein kinase D signaling is a
positive regulation of RIG-I signaling pathway is a
positive regulation of signal transduction by p53 class mediator is a
positive regulation of small GTPase mediated signal transduction is a
positive regulation of stress-activated protein kinase signaling cascade is a
positive regulation of TOR signaling is a
positive regulation of intracellular steroid hormone receptor signaling pathway is a
positive regulation of lipopolysaccharide-mediated signaling pathway is a
positive regulation of nerve growth factor receptor activity is a
positive regulation of netrin-activated signaling pathway is a
positive regulation of neuronal signal transduction is a
positive regulation of neurotrophin TRK receptor signaling pathway is a
positive regulation of Notch signaling pathway is a
positive regulation of pattern recognition receptor signaling pathway is a
positive regulation of peptidoglycan recognition protein signaling pathway is a
positive regulation of peroxisome proliferator activated receptor signaling pathway is a
positive regulation of platelet-derived growth factor receptor signaling pathway is a
positive regulation of receptor signaling pathway via STAT is a
positive regulation of red or far-red light signaling pathway is a
positive regulation of retinoic acid receptor signaling pathway is a
positive regulation of Roundabout signaling pathway is a
positive regulation of salicylic acid mediated signaling pathway is a
positive regulation of semaphorin-plexin signaling pathway is a
positive regulation of sevenless signaling pathway is a
positive regulation of signal transduction by receptor internalization is a
positive regulation of signal transduction involved in conjugation with cellular fusion is a
positive regulation of smoothened signaling pathway is a
positive regulation of sphingolipid mediated signaling pathway is a
positive regulation of SREBP signaling pathway is a
positive regulation of thyroid hormone mediated signaling pathway is a
positive regulation of Toll signaling pathway is a
positive regulation of torso signaling pathway is a
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is a
positive regulation of vascular endothelial growth factor receptor signaling pathway is a
positive regulation of vascular endothelial growth factor signaling pathway is a
positive regulation of vitamin D receptor signaling pathway is a
positive regulation of Wnt signaling pathway is a
positive regulation of synaptic transmission is a
positive regulation of transmission of nerve impulse is a
positive regulation of Wnt protein secretion is a
positive regulation of cell cycle is a
positive regulation of cell death is a
positive regulation of cell differentiation is a
positive regulation of cell division is a
positive regulation of cell growth is a
positive regulation of cell killing is a
positive regulation of cell population proliferation is a
positive regulation of cell wall organization or biogenesis is a
positive regulation of cellular component biogenesis is a
positive regulation of cellular component movement is a
positive regulation of cellular component organization is a
positive regulation of cellular metabolic process is a
positive regulation of cellular pH reduction is a
positive regulation of cellular protein localization is a
positive regulation of cellular response to alcohol is a
positive regulation of cellular response to drug is a
positive regulation of cellular response to gamma radiation is a
positive regulation of cellular response to heat is a
positive regulation of cellular response to hepatocyte growth factor stimulus is a
positive regulation of cellular response to hypoxia is a
positive regulation of cellular response to insulin stimulus is a
positive regulation of cellular response to macrophage colony-stimulating factor stimulus is a
positive regulation of cellular response to manganese ion is a
positive regulation of cellular response to oxidative stress is a
positive regulation of cellular response to oxidopamine is a
positive regulation of cellular response to thapsigargin is a
positive regulation of cellular response to transforming growth factor beta stimulus is a
positive regulation of cellular response to tunicamycin is a
positive regulation of cellular response to very-low-density lipoprotein particle stimulus is a
positive regulation of cellular response to X-ray is a
positive regulation of chromosome segregation is a
positive regulation of conjugation is a
positive regulation of cytolysis is a
positive regulation of establishment of bipolar cell polarity is a
positive regulation of establishment or maintenance of cell polarity regulating cell shape is a
positive regulation of horizontal cell localization is a
positive regulation of intracellular mRNA localization is a
positive regulation of intracellular transport is a
positive regulation of melanosome transport is a
positive regulation of myelination is a
positive regulation of peroxidase activity is a
positive regulation of phagocytosis is a
positive regulation of phenotypic switching is a
positive regulation of protein folding is a
positive regulation of response to cell cycle checkpoint signaling is a
positive regulation of response to DNA damage stimulus is a
positive regulation of response to endoplasmic reticulum stress is a
positive regulation of ribonucleoprotein complex localization is a
positive regulation of secretion by cell is a
positive regulation of sequestering of calcium ion is a
positive regulation of sequestering of zinc ion is a
positive regulation of serotonin uptake is a
positive regulation of single-species biofilm formation is a
positive regulation of stomatal opening is a
positive regulation of synaptic vesicle clustering is a
positive regulation of synaptic vesicle recycling is a
positive regulation of synaptic vesicle transport is a
positive regulation of transcytosis is a
positive regulation of transmembrane transport is a
positive regulation of transposition is a
positive regulation of vacuolar transport is a
positive regulation of vesicle docking is a
positive regulation of circadian rhythm is a
positive regulation of developmental pigmentation is a
positive regulation of developmental process is a
positive regulation of DNA-binding transcription factor activity is a
positive regulation of dosage compensation by inactivation of X chromosome is a
positive regulation of establishment of protein localization is a
positive regulation of establishment of RNA localization to telomere is a
positive regulation of growth is a
positive regulation of guanyl-nucleotide exchange factor activity is a
positive regulation of hemostasis is a
positive regulation of immune system process is a
positive regulation of lipid localization is a
positive regulation of locomotion is a
positive regulation of membrane depolarization is a
positive regulation of membrane hyperpolarization is a
positive regulation of metabolic process is a
positive regulation of mRNA alternative polyadenylation is a
positive regulation of multi-organism process is a
positive regulation of multicellular organismal process is a
positive regulation of nitrogen utilization is a
positive regulation of phosphorus utilization is a
positive regulation of posttranscriptional gene silencing is a
positive regulation of protein localization to cell-cell junction is a
positive regulation of protein localization to synapse is a
positive regulation of reproductive process is a
positive regulation of response to stimulus is a
positive regulation of short-term synaptic potentiation is a
positive regulation of signaling is a
positive regulation of sulfur utilization is a
positive regulation of telomerase RNA localization to Cajal body is a
positive regulation of transport is a
positive regulation of viral process is a
regulation of action potential is a
regulation of asexual reproduction is a
regulation of biomineralization is a
regulation of carbohydrate utilization is a
regulation of carbon utilization is a
regulation of cellular process is a
cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
regulation of cell activation is a
regulation of cell adhesion molecule production is a
regulation of cell aging is a
regulation of cell communication is a
regulation of cell cycle is a
regulation of cell death is a
regulation of cell differentiation is a
regulation of cell division is a
regulation of cell killing is a
regulation of cell population proliferation is a
regulation of cell wall organization or biogenesis is a
regulation of cellular component biogenesis is a
regulation of cellular component movement is a
regulation of cellular component organization is a
regulation of cellular localization is a
regulation of cellular metabolic process is a
regulation of cellular pH reduction is a
regulation of cellular response to alcohol is a
regulation of cellular response to alkaline pH is a
regulation of cellular response to drug is a
regulation of cellular response to gamma radiation is a
regulation of cellular response to growth factor stimulus is a
regulation of cellular response to insulin stimulus is a
regulation of cellular response to macrophage colony-stimulating factor stimulus is a
regulation of cellular response to manganese ion is a
regulation of cellular response to oxidopamine is a
regulation of cellular response to stress is a
regulation of cellular response to testosterone stimulus is a
regulation of cellular response to thapsigargin is a
regulation of cellular response to tunicamycin is a
regulation of cellular response to very-low-density lipoprotein particle stimulus is a
regulation of cellular response to X-ray is a
regulation of chromosome segregation is a
regulation of conjugation is a
regulation of cytolysis is a
regulation of establishment or maintenance of cell polarity is a
regulation of horizontal cell localization is a
regulation of membrane depolarization is a
regulation of microtubule-based process is a
regulation of myelination is a
regulation of peroxidase activity is a
regulation of phenotypic switching is a
regulation of protein folding is a
regulation of response to cell cycle checkpoint signaling is a
regulation of secretion by cell is a
regulation of single-species biofilm formation is a
regulation of stomatal movement is a
regulation of transmembrane transport is a
regulation of transposition is a
regulation of vacuolar transport is a
regulation of vesicle-mediated transport is a
signal transduction is a
apoptotic signaling pathway is a
bile acid signaling pathway is a
calmodulin dependent kinase signaling pathway is a
carbohydrate mediated signaling is a
cell surface receptor signaling pathway is a
chloroplast-nucleus signaling pathway is a
dopamine receptor signaling pathway is a
endoplasmic reticulum unfolded protein response is a
ER-nucleus signaling pathway is a
extracellular ATP signaling is a
G protein-coupled receptor signaling pathway is a
hormone-mediated signaling pathway is a
hydrogen peroxide mediated signaling pathway is a
hypoxia-inducible factor-1alpha signaling pathway is a
immune response-regulating signaling pathway is a
intracellular receptor signaling pathway is a
intracellular signal transduction is a
endosomal signal transduction is a
hippo signaling is a
inositol lipid-mediated signaling is a
MAPK cascade is a
ERK1 and ERK2 cascade is a
ERK5 cascade is a
MAP kinase activity part of
MAPK cascade involved in ascospore formation is a
MAPK cascade involved in axon regeneration is a
MAPK cascade involved in innate immune response is a
stress-activated MAPK cascade is a
phosphorelay signal transduction system is a
PKR signal transduction is a
protein kinase A signaling is a
protein kinase B signaling is a
protein kinase C signaling is a
protein kinase D signaling is a
RAM/MOR signaling pathway is a
second-messenger-mediated signaling is a
signal transduction by p53 class mediator is a
signal transduction in response to DNA damage is a
small GTPase mediated signal transduction is a
stress-activated protein kinase signaling cascade is a
TOR signaling is a
TRAF-mediated signal transduction is a
ligand-gated ion channel signaling pathway is a
lipoprotein particle mediated signaling is a
mitochondria-nucleus signaling pathway is a
necroptotic signaling pathway is a
neuronal signal transduction is a
osmosensory signaling pathway is a
pattern recognition receptor signaling pathway is a
peptidoglycan recognition protein signaling pathway is a
phototransduction is a
postsynaptic signal transduction is a
presynaptic signal transduction is a
receptor ligand activity part of
red or far-red light signaling pathway is a
regulation of blood pressure by chemoreceptor signaling pathway is a
regulation of floral organ abscission by signal transduction is a
salicylic acid mediated signaling pathway is a
serotonin receptor signaling pathway is a
signal transduction by conformational transition is a
signal transduction by protein phosphorylation is a
signal transduction in absence of ligand is a
signal transduction involved in cellular response to ammonium ion is a
signal transduction involved in filamentous growth is a
signal transduction involved in regulation of gene expression is a
sphingolipid mediated signaling pathway is a
regulation of circadian rhythm is a
regulation of developmental pigmentation is a
regulation of developmental process is a
regulation of estrogen receptor binding is a
regulation of growth is a
regulation of guanyl-nucleotide exchange factor activity is a
regulation of hemostasis is a
regulation of immune system process is a
regulation of interspecies interactions between organisms is a
regulation of localization is a
regulation of locomotion is a
regulation of membrane hyperpolarization is a
regulation of metabolic process is a
regulation of multi-organism process is a
regulation of multicellular organismal process is a
regulation of nitrogen utilization is a
regulation of phosphorus utilization is a
regulation of plasma lipoprotein particle levels is a
regulation of reproductive process is a
regulation of response to stimulus is a
regulation of signaling is a
regulation of sulfur utilization is a
regulation of biological quality is a
regulation of molecular function is a
biomineralization is a
carbohydrate utilization is a
carbon utilization is a
cellular process is a
detoxification is a
developmental process is a
growth is a
immune system process is a
interspecies interaction between organisms is a
intraspecies interaction between organisms is a
localization is a
locomotion is a
metabolic process is a
multi-organism process is a
multicellular organismal process is a
pigmentation is a
reproduction is a
response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a