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Gene ontology
Version 2014-12-22
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Details for ERK1 and ERK2 cascade
Gene ontology ID
GO:0070371
Definition
An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade may involve 4 different kinases, as it can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell
Comment
Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2 and should not be confused with cascades that involve other ERK kinases.
Synonyms
1. ERK cascade
2. ERK1 and ERK2 signaling pathway
3. ERK1 and ERK2 signalling pathway
4. ERK1 cascade
5. ERK1/2 cascade
6. ERK2 cascade
7. extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
8. extracellular signal-regulated kinase 1/2 cascade
9. MAPK1 cascade
10. MAPK3 cascade
References
1. GOC: add
2. GOC: signaling
3. ISBN 0121245462
4. ISBN 0896039986
5. PMID 20811974
6. PMID 28903453
Legend
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Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
regulation of cellular process is a
signal transduction is a
intracellular signal transduction is a
MAPK cascade is a
ERK1 and ERK2 cascade is a
Tree view
Gene ontology
biological_process is a
behavior is a
biological adhesion is a
biological phase is a
biological regulation is a
negative regulation of phosphatidylcholine metabolic process is a
regulation of biological process is a
modulation of host virulence by virus is a
negative regulation of biological process is a
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regulation of carbohydrate utilization is a
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cell redox homeostasis is a
modulation by symbiont of host cellular process is a
regulation of actin filament-based process is a
regulation of binding of sperm to zona pellucida is a
regulation of cartilage condensation is a
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regulation of cell adhesion molecule production is a
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response to stimulus is a
rhythmic process is a
signaling is a
cellular_component is a
molecular_function is a