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Gene ontology
Version 2014-12-22
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Details for MAPK cascade
Gene ontology ID
GO:0000165
Definition
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell
Comment
MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier.
Synonyms
1. ERK/MAPK cascade
2. MAP kinase cascade
3. MAP kinase kinase kinase cascade
4. MAPK signal transduction
5. MAPK signaling
6. MAPK signalling
7. MAPKKK cascade
8. MAPKKK cascade during sporulation
9. mitogen-activated protein kinase cascade
References
1. GOC: bf
2. GOC: mtg signaling feb11
3. PMID 20811974
4. PMID 9561267
5. Wikipedia: MAPK cascade
6. Wikipedia: Mitogen-activated protein kinase
Legend
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Condensed Tree View
Gene ontology
biological_process is a
biological regulation is a
regulation of biological process is a
regulation of cellular process is a
signal transduction is a
intracellular signal transduction is a
MAPK cascade is a
Tree view
Gene ontology
biological_process is a
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