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Gene ontology
Version 2014-12-22
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Details for DNA-binding transcription factor activity
Gene ontology ID
GO:0003700
Definition
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons
Comment
Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes.
Synonyms
1. bacterial-type DNA binding transcription factor activity
2. bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity
3. bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity
4. bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
5. bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding
6. DNA binding transcription factor activity
7. gene-specific transcription factor activity
8. metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
9. metal ion regulated sequence-specific DNA binding transcription factor activity
10. nucleic acid binding transcription factor activity
11. sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity
12. sequence-specific DNA binding transcription factor activity
13. transcription factor activity
14. transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding
15. transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding
16. transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding
17. transcription factor activity, metal ion regulated sequence-specific DNA binding
References
1. GOC: txnOH-2018
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