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Information on EC 4.2.1.152 - hydroperoxy icosatetraenoate dehydratase

for references in articles please use BRENDA:EC4.2.1.152

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IUBMB Comments

Binds Fe2+. The mammalian enzymes accept a range of hydroperoxyicosatetraenoates (HPETE). The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency. The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE) . The enzymes also catalyse the reaction of EC 5.4.4.7, hydroperoxy icosatetraenoate isomerase.

The enzyme appears in viruses and cellular organisms

Synonyms
aloxe3, elox-3, hepoxilin synthase, epidermis-type lipoxygenase 3, epidermal lox type 3, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
a hydroperoxyicosatetraenoate = an oxoicosatetraenoate + H2O
show the reaction diagram
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PATHWAY SOURCE
PATHWAYS
Highest Expressing Human Cell Lines
Cell Line Links Gene Links