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Literature summary for 4.2.1.152 extracted from

  • Yu, Z.; Schneider, C.; Boeglin, W.E.; Brash, A.R.
    Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3 (2005), Biochim. Biophys. Acta, 1686, 238-247.
    View publication on PubMed
Search for more literature for 4.2.1.152

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and COS7 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
R396S inactive Homo sapiens
V500F inactive Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(12R)-HPETE Homo sapiens preferred substrate (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O
-
 ?
(15S)-HPETE Homo sapiens
-
 (15S)HETE + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(12R)-HPETE preferred substrate Homo sapiens (8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid + H2O
-
 ?
(15S)-HPETE
-
 Homo sapiens (15S)HETE + H2O
-
 ?

Synonyms

Synonyms Comment Organism
eLOX3
-
 Homo sapiens
epidermal lipoxygenase-3
-
 Homo sapiens
hepoxilin synthase
-
 Homo sapiens