Literature summary for 4.2.1.152 extracted from

Vierling, F.; Dick, A.; Wahlbuhl, M.; Krieg, P.; Henke, C.; Ruebner, M.; Schneider, H.
Surprising prenatal toxicity of epidermal lipoxygenase-3 (2014), Placenta, 35, 776-779 .

Search for more literature for 4.2.1.152

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q9WV07	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	-	Mus musculus	-
placenta	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
ALOXE3	-	Mus musculus
eLOX-3	-	Mus musculus
epidermal lipoxygenase-3	-	Mus musculus

General Information

General Information	Comment	Organism
malfunction	mutations in nine different genes are known to be responsible for ichthyoses. One of them is the lipoxygenase gene Aloxe3 encoding the epidermal lipoxygenase-3 (eLOX-3). eLOX-3-deficient mice decease rapidly after birth due to transepidermal water loss, short life-span of eLOX-3 null mice. For a prenatal gene therapy approach, intra-amniotic delivery of eLOX-3 to mice at gestational day 14.5, both via an adenoviral vector and as recombinant protein, is undertaken resulting in fetal growth restriction and intrauterine death. Periodic acid-Schiff staining and RT-PCR analysis of placentae from fetuses exposed to eLOX-3 indicate a lack of glycogen trophoblasts in the junctional zone, overview. Placenta-specific gene expression is altered. Thus, the observed prenatal toxicity of eLOX-3 can be due to a strong effect on placental development	Mus musculus
physiological function	the epidermal lipoxygenase-3 (eLOX-3) is involved in the conversion of fatty acids to specific epoxyalcohol derivatives such as ceramide precursors and hepoxilins and plays an important role in the generation of the permeability barrier of the skin, which protects against dehydration and physical injury. eLOX-3 appears to have some impact on the expression of genes that indirectly influence fetal development	Mus musculus

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Release 2023.1 (January 2023)