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Literature summary for 4.2.1.152 extracted from

  • Zheng, Y.; Brash, A.R.
    Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids (2010), J. Biol. Chem., 285, 39866-39875.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.152

Activating Compound

Activating Compound Comment Organism Structure
(13S)-HPODE
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Protein Variants

Protein Variants Comment Organism
A451G unlike wild type enzyme, the mutant reacts well with arachidonic acid even in the absence of fatty acid hydroperoxides, yet only after an unusually long lag phase of about 20 min Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(9E,11Z,14Z)-20:3omega6 good substrate Homo sapiens (9S)-hydroperoxy-(10E,12E,14Z)-eicosatrienoic acid + H2O
-
 ?
arachidonic acid + O2 in the absence of fatty acid hydroperoxides, the enzyme shows only weak and slow activity with arachidonic acid Homo sapiens 5-HPETE + 7-HPETE + 9-HPETE 22%, 25%, and 29% yield, respectively ?
arachidonoyl-lysophosphatidic acid
-
 Homo sapiens 15-HPETE-lysophosphatidic acid + 13-HPETE-lysophosphatidic acid + 11HPETE-lysophosphatidic acid + 5-HPETE-lysophosphatidic acid + H2O 36%, 22%, 21%, and 13% yield, respectively ?

Synonyms

Synonyms Comment Organism
eLOX3
-
 Homo sapiens
epidermal lipoxygenase-3
-
 Homo sapiens