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Information on EC 4.1.3.39 - 4-hydroxy-2-oxovalerate aldolase

for references in articles please use BRENDA:EC4.1.3.39

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IUBMB Comments

Requires Mn2+ for maximal activity . The enzyme from the bacterium Pseudomonas putida is also stimulated by NADH . In some bacterial species the enzyme forms a bifunctional complex with EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase [4,5].

The enzyme appears in viruses and cellular organisms

Synonyms
4-hydroxy-2-oxovalerate aldolase, 4-hydroxy-2-ketovalerate aldolase, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
(S)-4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate
show the reaction diagram