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Information on EC 3.7.1.2 - fumarylacetoacetase and Organism(s) Arabidopsis thaliana and UniProt Accession Q8RW90
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3.7.1.2 fumarylacetoacetaseIUBMB Comments
Also acts on other 3,5- and 2,4-dioxo acids.
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Word Map
- 3.7.1.2
- tyrosinemia
- hereditary
- flavone
- hepatocytes
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anticipatory
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aviation
- succinylacetone
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schedule
-
oscillator
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rhythm
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circadian
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entrain
-
frontal
- ntbc
-
flight
- meal
-
asymmetry
- clock
-
federal
-
aircraft
-
locomotor
-
fanconi
-
repopulation
-
food-entrainable
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suprachiasmatic
-
civil
- taurine
-
n-2-fluorenylacetamide
- accident
-
certification
-
antitumour
- medicine
- homogentisate
- 4-hydroxyphenylpyruvate
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mealtime
- maleylacetoacetate
-
rickets
-
aerospace
-
dorsomedial
- xaa
-
electroencephalography
-
hepatorenal
-
civilian
-
zeitgeber
- 4-aminoantipyrine
-
anteversion
-
dipyrone
-
light-entrainable
- biotechnology
- degradation
The taxonomic range for the selected organisms is: Arabidopsis thaliana
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
The expected taxonomic range for this enzyme is: Bacteria, Eukaryota, Archaea
Synonyms
faa, fumarylacetoacetate hydrolase, fumarylacetoacetase, sscd1, eafah, atfah, acylpyruvase, ttha0809, faa hydrolase, 
more
topSYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
4-fumarylacetoacetate fumarylhydrolase
-
-
-
-
acylpyruvase
-
-
-
-
beta-diketonase
-
-
-
-
diketo acid hydrolase
-
-
-
-
FAA
-
-
-
-
FAH
fumarylacetoacetate hydrolase
FAH
-
-
-
-
fumarylacetoacetate hydrolase
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of C-C bond
-
-
-
-
PATHWAY SOURCE
PATHWAYS
BRENDA
-
-
SYSTEMATIC NAME
IUBMB Comments
4-fumarylacetoacetate fumarylhydrolase
Also acts on other 3,5- and 2,4-dioxo acids.
CAS REGISTRY NUMBER
COMMENTARY
9032-59-1
-
SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
-
-
-
?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
final step in the Tyr degradation pathway
-
-
?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
the enzyme catalyzes the last step in the Tyr degradation pathway
-
-
?
NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
final step in the Tyr degradation pathway
-
-
?
4-fumarylacetoacetate + H2O
acetoacetate + fumarate
the enzyme catalyzes the last step in the Tyr degradation pathway
-
-
?
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
IMAGE
succinylacetone
treatment of wild-type seedlings with succinylacetone mimicks the sscd1 phenotypes: the treated wild-type seedlings exhibit wilted leaves and slow-growth symptoms under long-day, these symptoms are more severe under short-day. The sscd1 mutant is more sensitive to succinylacetone than the wild type under long-day
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SOURCE
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
malfunction
metabolism
fumarylacetoacetate hydrolase hydrolyzes fumarylacetoacetate to fumarate and acetoacetate, the final step in the tyrosine degradation pathway that is essential for plant survival under short-day conditions
physiological function
malfunction
an Arabidopsis thaliana short-day sensitive cell death1 (sscd1) mutant displays a spontaneous cell death phenotype under short-day conditions, disruption of FAH leads to cell death, phenotype overview. The spontaneous cell death phenotype of the sscd1 mutant is completely eliminated by further knockout of the gene encoding the putative homogentisate dioxygenase, which catalyzes homogentisate into maleylacetoacetate (the antepenultimate step) in the Tyr degradation pathway. Treatment of Arabidopsis wild-type seedlings with succinylacetone, an abnormal metabolite caused by loss of FAH in the Tyr degradation pathway, mimicks the sscd1 cell death phenotype
malfunction
lethal phenotype of the short-day sensitive cell death1 (sscd1) seedlings resulting from the loss of fumarylacetoacetate hydrolase
malfunction
the sscd1 mutant is hypersensitive to salt stress. The sscd1 mutant shows more accumulation of reactive oxygen species (ROS) and less up-regulation of some ROS-scavenging genes such as ASCORBATE PEROXIDASE 2 and COPPER/ZINC SUPEROXIDE DISMUTASE 1 compared with wild type under salt stress. The sscd1 mutant exhibits hypersensitivity to oxidative stress compared with wild type enzyme. Loss of fumarylacetoacetate hydrolase in sscd1 mutant leads to the accumulation of Tyr degradation intermediates, which impairs the up-regulation of some ROS-scavenging genes under salt stress, causing more accumulation of ROS, resulting in the hypersensitivity of sscd1 to salt stress
physiological function
the enzyme catalyzes the last step in the Tyr degradation pathway
UNIPROT
ENTRY NAME
ORGANISM
NO. OF AA
NO. OF TRANSM. HELICES
MOLECULAR WEIGHT[Da]
SOURCE
SEQUENCE
LOCALIZATION PREDICTION
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable).
The reliability class of the localization prediction ranges from 1 (very reliable) to 5 (not reliable). FAH_ARATH
421
0
46095
Swiss-Prot
other Location (Reliability: 2)
MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
SUBUNIT
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
monomer or dimer
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gel filtration analysis gives an estimated molecular mass of 65000 Da which is an equivalent to 1.4 monomers
PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
additional information
isolation and analysis of the sscd1-1 mutant. Generation of the sscd1 hgo double mutant through genetic crossing of sscd1-1 with hgo-1, an inactive homogentisate dioxygenase mutant, phenotypic analysis
PURIFICATION (Commentary)
ORGANISM
UNIPROT
LITERATURE
CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
SSCD1 gene, DNA and amino acid sequence determination and analysis, map-based cloning
EXPRESSION
ORGANISM
UNIPROT
LITERATURE
APPLICATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
biotechnology
-
participation in the synthesis of vitamin E and other tocopherols
REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Dixon, D.P.; Edwards, R.
Enzymes of tyrosine catabolism in Arabidopsis thaliana
Plant Sci.
171
360-366
2006
Arabidopsis thaliana
Han, C.; Ren, C.; Zhi, T.; Zhou, Z.; Liu, Y.; Chen, F.; Peng, W.; Xie, D.
Disruption of fumarylacetoacetate hydrolase causes spontaneous cell death under short-day conditions in Arabidopsis
Plant Physiol.
162
1956-1964
2013
Arabidopsis thaliana (Q8RW90)
Zhi, T.; Zhou, Z.; Huang, Y.; Han, C.; Liu, Y.; Zhu, Q.; Ren, C.
Sugar suppresses cell death caused by disruption of fumarylacetoacetate hydrolase in Arabidopsis
Planta
244
557-571
2016
Arabidopsis thaliana (Q8RW90)
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