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Literature summary for 3.7.1.2 extracted from

  • Huang, L.; Hu, C.; Cai, W.; Zhu, Q.; Gao, B.; Zhang, X.; Ren, C.
    Fumarylacetoacetate hydrolase is involved in salt stress response in Arabidopsis (2018), Planta, 248, 499-511 .
    View publication on PubMed
Search for more literature for 3.7.1.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-fumarylacetoacetate + H2O Arabidopsis thaliana final step in the Tyr degradation pathway acetoacetate + fumarate
-
 ?
4-fumarylacetoacetate + H2O Arabidopsis thaliana Col-0 final step in the Tyr degradation pathway acetoacetate + fumarate
-
 ?

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana Q8RW90
-
-
Arabidopsis thaliana Col-0 Q8RW90
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-fumarylacetoacetate + H2O
-
 Arabidopsis thaliana acetoacetate + fumarate
-
 ?
4-fumarylacetoacetate + H2O final step in the Tyr degradation pathway Arabidopsis thaliana acetoacetate + fumarate
-
 ?
4-fumarylacetoacetate + H2O
-
 Arabidopsis thaliana Col-0 acetoacetate + fumarate
-
 ?
4-fumarylacetoacetate + H2O final step in the Tyr degradation pathway Arabidopsis thaliana Col-0 acetoacetate + fumarate
-
 ?

Synonyms

Synonyms Comment Organism
fumarylacetoacetate hydrolase
-
 Arabidopsis thaliana
SSCD1
-
 Arabidopsis thaliana

Expression

Organism Comment Expression
Arabidopsis thaliana the SSCD1 gene is up-regulated by salt stress and by H2O2 up

General Information

General Information Comment Organism
malfunction the sscd1 mutant is hypersensitive to salt stress. The sscd1 mutant shows more accumulation of reactive oxygen species (ROS) and less up-regulation of some ROS-scavenging genes such as ASCORBATE PEROXIDASE 2 and COPPER/ZINC SUPEROXIDE DISMUTASE 1 compared with wild type under salt stress. The sscd1 mutant exhibits hypersensitivity to oxidative stress compared with wild type enzyme. Loss of fumarylacetoacetate hydrolase in sscd1 mutant leads to the accumulation of Tyr degradation intermediates, which impairs the up-regulation of some ROS-scavenging genes under salt stress, causing more accumulation of ROS, resulting in the hypersensitivity of sscd1 to salt stress Arabidopsis thaliana
physiological function final step in the Tyr degradation pathway Arabidopsis thaliana