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Ligand fumarate

Basic Ligand Information

Molecular Structure

Pathway Source

Pathways

BRENDA

3-phenylpropionate degradation, arginine metabolism, citric acid cycle, glutamate and glutamine metabolism, methylaspartate cycle, propionate fermentation, purine metabolism, toluene degradation, tyrosine metabolism, urea cycle more

KEGG

Alanine, aspartate and glutamate metabolism, Arginine biosynthesis, Biosynthesis of alkaloids derived from histidine and purine, Biosynthesis of alkaloids derived from ornithine, lysine and nicotinic acid, Biosynthesis of alkaloids derived from shikimate pathway, Biosynthesis of alkaloids derived from terpenoid and polyketide, Biosynthesis of phenylpropanoids, Biosynthesis of plant hormones, Biosynthesis of plant secondary metabolites, Biosynthesis of secondary metabolites, Biosynthesis of terpenoids and steroids, Butanoate metabolism, Carbon fixation pathways in prokaryotes, Carbon metabolism, Central carbon metabolism in cancer, Citrate cycle (TCA cycle), Degradation of aromatic compounds, Glucagon signaling pathway, Microbial metabolism in diverse environments, Nicotinate and nicotinamide metabolism, Oxidative phosphorylation, Pathways in cancer, Phenylalanine metabolism, Pyruvate metabolism, Renal cell carcinoma, Styrene degradation, Two-component system, Tyrosine metabolism more

MetaCyc

(S)-lactate fermentation to propanoate, acetate and hydrogen, 5-nitroanthranilate degradation, adenosine ribonucleotides de novo biosynthesis, aerobic respiration I (cytochrome c), aerobic respiration II (cytochrome c) (yeast), aerobic respiration III (alternative oxidase pathway), anaerobic energy metabolism (invertebrates, mitochondrial), canavanine biosynthesis, cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate, dapdiamides biosynthesis, dZTP biosynthesis, gentisate degradation I, glycerol-3-phosphate to fumarate electron transfer, hydrogen to fumarate electron transfer, incomplete reductive TCA cycle, inosine-5'-phosphate biosynthesis I, inosine-5'-phosphate biosynthesis II, inosine-5'-phosphate biosynthesis III, L-arginine biosynthesis I (via L-ornithine), L-arginine biosynthesis II (acetyl cycle), L-arginine biosynthesis III (via N-acetyl-L-citrulline), L-arginine biosynthesis IV (archaea), L-aspartate degradation II (aerobic), L-aspartate degradation II (anaerobic), L-glutamate degradation II, L-tyrosine degradation I, m-xylene degradation (anaerobic), methylaspartate cycle, mixed acid fermentation, NAD de novo biosynthesis IV (anaerobic), NADH to fumarate electron transfer, nicotinate degradation I, nicotinate degradation II, nicotine degradation II (pyrrolidine pathway), nicotine degradation III (VPP pathway), nitric oxide biosynthesis II (mammals), nitrite biosynthesis, partial TCA cycle (obligate autotrophs), picolinate degradation, pyruvate fermentation to propanoate I, reductive TCA cycle I, reductive TCA cycle II, succinate to chytochrome c oxidase via cytochrome c6, succinate to cytochrome bd oxidase electron transfer, succinate to cytochrome bo oxidase electron transfer, succinate to cytochrome c oxidase via plastocyanin, succinate to plastoquinol oxidase, superpathway of glyoxylate cycle and fatty acid degradation, superpathway of L-aspartate and L-asparagine biosynthesis, TCA cycle I (prokaryotic), TCA cycle II (plants and fungi), TCA cycle III (animals), TCA cycle IV (2-oxoglutarate decarboxylase), TCA cycle V (2-oxoglutarate synthase), TCA cycle VI (Helicobacter), TCA cycle VII (acetate-producers), TCA cycle VIII (Chlamydia), tetrahydromethanopterin biosynthesis, toluene degradation to benzoyl-CoA (anaerobic), toyocamycin biosynthesis, UMP biosynthesis II, urea cycle more

Show all BRENDA pathways known for fumarate

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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (19 results)

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Show Natural Substrate (19 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.6

fumarate + NADH + H+ = succinate + NAD+

390836, 390838, 699012, 655610, 656728, 390844, 390835, 390840, 390843, 740879, 740826, 390839, 657430, 390837, 390841, 390842, 740822, 740157, 740858, 739918

-

1.3.4.1

fumarate + CoM + CoB = succinate + CoM-S-S-CoB

723990

-

1.3.5.1

fumarate + menaquinol = succinate + menaquinone

391137

5xmj, 3D-view

1.3.5.1

fumarate + reduced acceptor = succinate + acceptor

674283, 724407

5xmj, 3D-view

1.3.5.4

fumarate + 2,3-dimethyl-1,4-naphthohydroquinone = succinate + 2,3-dimethyl-1,4-naphthoquinone

391084

-

1.3.5.4

fumarate + a menaquinol = succinate + a menaquinone

700278

-

1.3.5.4

fumarate + menaquinol = succinate + menaquinone

391089, 391090

-

1.3.98.1

(S)-dihydroorotate + fumarate = orotate + succinate

740019, 656747, 741111

-

1.3.98.1

L-dihydroorotate + fumarate = orotate + succinate

711915, 710846

-

1.4.3.16

L-aspartate + fumarate = iminosuccinate + succinate

711324

-

1.4.3.16

L-aspartate + H2O + fumarate = oxaloacetate + NH3 + succinate

656090

-

4.1.99.11

toluene + fumarate = benzylsuccinate

749165, 748195, 210661, 747978, 748432, 677932, 210659, 210662, 679528, 210660, 210658, 692113, 678164, 691008, 210663

5bwd, 3D-view

4.1.99.11

toluene + fumarate = benzylsuccinate

679528, 677932, 692113, 210661, 678164, 749165, 747978, 748432, 210659, 210662, 210660, 210658, 691008, 210663, 748195

5bwe, 3D-view

4.2.1.2

fumarate + H2O = L-malate

653794, 653454, 651690, 651522

4apb, 3D-view

4.2.1.2

fumarate + H2O = L-malate

653794, 651522, 651690, 653454

6uqn, 3D-view

4.2.1.2

fumarate + H2O = L-malate

651522, 653794, 651690, 653454

7c18, 3D-view

1.3.5.1

2 entries

1.3.5.4

3 entries

1.3.98.1

2 entries

1.4.3.16

2 entries

4.1.99.11

2 entries

4.2.1.2

3 entries

4.3.1.1

fumarate + NH3 = L-aspartate

748406

6wng, 3D-view

4.3.2.1

fumarate + L-arginine = 2-(Nomega-L-arginino)succinate

729518

6ien, 3D-view

6.3.2.46

ATP + fumarate + (2S)-2,3-diaminopropionate = AMP + diphosphate + (2E)-4-[(2-amino-2-carboxyethyl)amino]-4-oxobut-2-enoate

729202

-

In Vivo Product in Enzyme-catalyzed Reactions (67 results)

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Show Natural Product (67 entries)

EC NUMBER

PROVEN IN VIVO REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.3.1.6

succinate + NAD+ = fumarate + NADH + H+

-

-

1.3.5.1

succinate + acceptor = fumarate + reduced acceptor

-

5xmj, 3D-view

1.3.5.1

succinate + caldariellaquinone = fumarate + caldariellaquinol

-

5xmj, 3D-view

1.3.5.1

succinate + electron acceptor = fumarate + reduced acceptor

-

5xmj, 3D-view

1.3.5.1

succinate + FAD = fumarate + FADH2

-

5xmj, 3D-view

1.3.5.1

succinate + menaquinone = fumarate + menaquinol

-

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone = fumarate + ubiquinol

391134, 391082, 391128, 391136, 2877, 391139, 391137, , 391143

5xmj, 3D-view

1.3.5.4

succinate + a menaquinone = fumarate + a menaquinol

-

-

1.3.5.4

succinate + rhodoquinone = fumarate + rhodoquinol

-

-

1.3.5.1

6 entries

1.3.5.4

2 entries

3.7.1.2

4-fumarylacetoacetate + H2O = acetoacetate + fumarate

289247, 289246, 289242, 289241, 289240, 289257, , 289245

1qco, 3D-view

4.1.1.112

fumarylpyruvate + H2O = fumarate + pyruvate + H+

-

-

4.1.99.11

benzylsuccinate = toluene + fumarate

-

5bwd, 3D-view

4.1.99.11

benzylsuccinate = toluene + fumarate

-

5bwe, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

-

4apb, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

-

6uqn, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

-

7c18, 3D-view

4.1.99.11

2 entries

4.2.1.2

3 entries

4.3.1.1

L-aspartate = fumarate + NH3

-

6wng, 3D-view

4.3.2.1

(Nomega-L-arginino)succinate = fumarate + L-arginine

651195, 651343, 650920, 652321, 653358, 652664, 650743, 652692, 650800, 650043, 650042

6ien, 3D-view

4.3.2.1

2-(Nomega-L-arginino)succinate = fumarate + L-arginine

-

6ien, 3D-view

4.3.2.1

argininosuccinate = fumarate + L-Arg

-

6ien, 3D-view

4.3.2.1

omega-N-(L-arginino)succinate = L-arginine + fumarate

-

6ien, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

2ptq, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

2vd6, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5hw2, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5nx9, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5nxa, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

2ptq, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

2vd6, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5hw2, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5nx9, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5nxa, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2ptq, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2vd6, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5hw2, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nx9, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nxa, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

2ptq, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

2vd6, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5hw2, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5nx9, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5nxa, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2ptq, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2vd6, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5hw2, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nx9, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nxa, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

2ptq, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

2vd6, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5hw2, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5nx9, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5nxa, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

-

2ptq, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

-

2vd6, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

-

5hw2, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

-

5nx9, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

-

5nxa, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

2ptq, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

2vd6, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5hw2, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5nx9, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5nxa, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

2ptq, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

2vd6, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5hw2, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5nx9, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5nxa, 3D-view

4.3.2.1

4 entries

4.3.2.2

45 entries

5.2.1.1

Maleate = Fumarate

-

-

Substrate in Enzyme-catalyzed Reactions (106 results)

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Show Substrate (106 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.12.99.6

H2 + fumarate = succinate

742788

-

1.3.1.6

fumarate + FADH2 = succinate + FAD

390839

-

1.3.1.6

fumarate + FMNH2 = succinate + FMN

390836, 390839

-

1.3.1.6

fumarate + NADH + H+ = succinate + NAD+

655610, 690208, 390838, 655266, 390836, 740858, 689320, 689694, 740157, 740822, 390842, 390843, 390841, 687075, 390840, 390837, 657430, 684492, 390835, 390839, 390844, 739918, 740826, 687076, 656280, 654657, 656728, 740879, 654680, 699012

-

1.3.1.6

fumarate + reduced benzylviologen = succinate + benzylviologen

675843

-

1.3.1.6

4 entries

1.3.4.1

fumarate + CoM + CoB = succinate + CoM-S-S-CoB

723990

-

1.3.5.1

fumarate + 2,3-dimethyl-1,4-naphthoquinol = succinate + 2,3-dimethyl-1,4-naphthoquinone

707470

5xmj, 3D-view

1.3.5.1

fumarate + electron donor = succinate + oxidized donor

391191, 391168, 391170, 391172, 391173, 391169, 391189, 391092, 391091, 391171

5xmj, 3D-view

1.3.5.1

fumarate + menaquinol = succinate + menaquinone

391137

5xmj, 3D-view

1.3.5.1

fumarate + naphthoquinol = succinate + naphthoquinone

391134

5xmj, 3D-view

1.3.5.1

fumarate + quinol = succinate + ubiquinone

391137, 391139

5xmj, 3D-view

1.3.5.1

fumarate + reduced 2,6-dichlorophenolindophenol = succinate + 2,6-dichlorophenolindophenol

391101

5xmj, 3D-view

1.3.5.1

fumarate + reduced acceptor = succinate + acceptor

674283, 724407

5xmj, 3D-view

1.3.5.1

fumarate + reduced benzyl viologen = succinate + benzyl viologen

708966, 708961, 674283

5xmj, 3D-view

1.3.5.1

fumarate + reduced benzyl viologen = succinate + oxidized benzyl viologen

724407

5xmj, 3D-view

1.3.5.1

fumarate + reduced decylubiquinone = succinate + decylubiquinone

707949

5xmj, 3D-view

1.3.5.1

fumarate + reduced phenazine methosulfate = succinate + phenazine methosulfate

707545

5xmj, 3D-view

1.3.5.1

fumarate + reduced plumbagin = succinate + oxidized plumbagin

685281

5xmj, 3D-view

1.3.5.4

2,3-dimethyl-1,4-naphthoquinol + fumarate = ?

724561

-

1.3.5.4

fumarate + 2,3-dimethyl-1,4-naphthohydroquinone = succinate + 2,3-dimethyl-1,4-naphthoquinone

391084, 391094, 391092, 391106

-

1.3.5.4

fumarate + 8-methylmenaquinol-6 = succinate + 8-methylmenaquinone-6

700278

-

1.3.5.4

fumarate + a menaquinol = succinate + a menaquinone

700278

-

1.3.5.4

fumarate + a quinol = succinate + a quinone

743059

-

1.3.5.4

fumarate + anthrahydroquinonesulfonate = succinate + anthraquinonesulfonate

391116, 391092

-

1.3.5.4

fumarate + menaquinol = succinate + ?

391089, 391090

-

1.3.5.4

fumarate + menaquinol = succinate + menaquinone

674634, 707470, 674532, 742846, 391089, 391090, 654820

-

1.3.5.4

fumarate + menaquinol-6 = succinate + menaquinone-6

708966

-

1.3.98.1

(S)-dihydroorotate + fumarate = orotate + succinate

724305, 710846, 656747, 724484, 740019, 741111

-

1.3.98.1

dihydroorotate + fumarate = orotate + ?

675478, 656148, 656747, 676289

-

1.3.98.1

dihydroorotate + fumarate = orotate + reduced fumarate

676859, 676289, 676964

-

1.3.98.1

dihydroorotate + fumarate = orotate + succinate

684848

-

1.3.98.1

L-dihydroorotate + fumarate = orotate + succinate

711915, 685146, 684914, 710846, 686821

-

1.3.98.1

S-dihydroorotate + fumarate = orotate + succinate

689056

-

1.4.3.16

L-aspartate + fumarate = iminosuccinate + succinate

711324

-

1.4.3.16

L-aspartate + H2O + fumarate = oxaloacetate + NH3 + succinate

656090, 686712

-

2.8.3.18

acetyl-CoA + fumarate = fumaryl-CoA + acetate

721675

-

2.8.3.18

succinyl-CoA + fumarate = fumaryl-CoA + succinate

721675

-

3.5.1.3

fumarate + H2O = ?

288886

-

3.5.1.3

fumarate + hydroxylamine = fumaryl hydroxamate + H2O

288886

-

4.1.99.11

2-fluorotoluene + fumarate = (2-fluorobenzyl)succinate

210660

5bwd, 3D-view

4.1.99.11

2-fluorotoluene + fumarate = (2-fluorobenzyl)succinate

210660

5bwe, 3D-view

4.1.99.11

3-fluorotoluene + fumarate = (3-fluorobenzyl)succinate

210660

5bwd, 3D-view

4.1.99.11

3-fluorotoluene + fumarate = (3-fluorobenzyl)succinate

210660

5bwe, 3D-view

4.1.99.11

4-fluorotoluene + fumarate = (4-fluorobenzyl)succinate

210660

5bwd, 3D-view

4.1.99.11

4-fluorotoluene + fumarate = (4-fluorobenzyl)succinate

210660

5bwe, 3D-view

4.1.99.11

benzaldehyde + fumarate = benzoylsuccinate

210660

5bwd, 3D-view

4.1.99.11

benzaldehyde + fumarate = benzoylsuccinate

210660

5bwe, 3D-view

4.1.99.11

m-cresol + fumarate = (3-hydroxybenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

m-cresol + fumarate = (3-hydroxybenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

m-xylene + fumarate = (3-methylbenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

m-xylene + fumarate = (3-methylbenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

m-xylene-d6 + fumarate = (3-methylbenzyl)succinate-d6

210660

5bwd, 3D-view

4.1.99.11

m-xylene-d6 + fumarate = (3-methylbenzyl)succinate-d6

210660

5bwe, 3D-view

4.1.99.11

o-cresol + fumarate = (2-hydroxybenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

o-cresol + fumarate = (2-hydroxybenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

o-xylene + fumarate = (2-methylbenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

o-xylene + fumarate = (2-methylbenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

o-xylene-d10 + fumarate = (2-methylbenzyl)succinate-d10

210660

5bwd, 3D-view

4.1.99.11

o-xylene-d10 + fumarate = (2-methylbenzyl)succinate-d10

210660

5bwe, 3D-view

4.1.99.11

p-cresol + fumarate = (4-hydroxybenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

p-cresol + fumarate = (4-hydroxybenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

p-xylene + fumarate = (4-methylbenzyl)succinic acid

663790

5bwd, 3D-view

4.1.99.11

p-xylene + fumarate = (4-methylbenzyl)succinic acid

663790

5bwe, 3D-view

4.1.99.11

p-xylene-d10 + fumarate = (4-methylbenzyl)succinate-d10

210660

5bwd, 3D-view

4.1.99.11

p-xylene-d10 + fumarate = (4-methylbenzyl)succinate-d10

210660

5bwe, 3D-view

4.1.99.11

toluene + fumarate = benzylsuccinate

210663, 663790, 691008, 692113, 210658, 210660, 210662, 210659, 748432, 703741, 747978, 748195, 749165, 210661, 677932, 679528, 678164, 704111

5bwd, 3D-view

4.1.99.11

toluene + fumarate = benzylsuccinate

210663, 663790, 691008, 692113, 210658, 210660, 210662, 210659, 748432, 703741, 747978, 748195, 749165, 210661, 677932, 679528, 678164, 704111

5bwe, 3D-view

4.1.99.11

[d3-methyl]toluene + fumarate = ?

665307

5bwd, 3D-view

4.1.99.11

[d3-methyl]toluene + fumarate = ?

665307

5bwe, 3D-view

4.2.1.2

fumarate + H2O = (S)-malate

749072, 745719, 746828

4apb, 3D-view

4.2.1.2

fumarate + H2O = (S)-malate

749072, 745719, 746828

6uqn, 3D-view

4.2.1.2

fumarate + H2O = (S)-malate

749072, 745719, 746828

7c18, 3D-view

4.2.1.2

fumarate + H2O = L-malate

33762, 651690, 33748, 33771, 697077, 698323, 653794, 33754, 703151, 33728, 33745, 699104, 33769, 33751, 33763, 695741, 700824, 33767, 33774, 730365, 651522, 679811, 747749, 749072, 653771, 729729, 746828, 653454

4apb, 3D-view

4.2.1.2

fumarate + H2O = L-malate

33762, 651690, 33748, 33771, 697077, 698323, 653794, 33754, 703151, 33728, 33745, 699104, 33769, 33751, 33763, 695741, 700824, 33767, 33774, 730365, 651522, 679811, 747749, 749072, 653771, 729729, 746828, 653454

6uqn, 3D-view

4.2.1.2

fumarate + H2O = L-malate

33762, 651690, 33748, 33771, 697077, 698323, 653794, 33754, 703151, 33728, 33745, 699104, 33769, 33751, 33763, 695741, 700824, 33767, 33774, 730365, 651522, 679811, 747749, 749072, 653771, 729729, 746828, 653454

7c18, 3D-view

4.2.1.2

fumaric acid + H2O = (S)-malic acid

657547

4apb, 3D-view

4.2.1.2

fumaric acid + H2O = (S)-malic acid

657547

6uqn, 3D-view

4.2.1.2

fumaric acid + H2O = (S)-malic acid

657547

7c18, 3D-view

4.2.1.2

fumaric acid + H2O = L-malic acid

659846

4apb, 3D-view

4.2.1.2

fumaric acid + H2O = L-malic acid

659846

6uqn, 3D-view

4.2.1.2

fumaric acid + H2O = L-malic acid

659846

7c18, 3D-view

4.2.1.34

fumarate + H2O = (S)-malate

746828, 749072

-

4.2.1.34

fumarate + H2O = L-malate

5666, 5668, 5667

-

4.3.1.1

fumarate + hydroxylamine = ?

5997, 5998, 6009, 6019

6wng, 3D-view

4.3.1.1

fumarate + hydroxylamine = L-aspartate

651803

6wng, 3D-view

4.3.1.1

fumarate + NH3 = L-aspartate

650750, 651803, 729405, 748406, 746796

6wng, 3D-view

4.3.1.1

fumarate + NH4Cl = ?

5998, 6009

6wng, 3D-view

4.3.1.1

hydrazine + fumarate = 2-hydrazinosuccinic acid

691802

6wng, 3D-view

4.3.1.1

hydroxylamine + fumarate = N-hydroxyaspartic acid

691802

6wng, 3D-view

4.3.1.1

methoxylamine + fumarate = N-methoxyaspartic acid

691802

6wng, 3D-view

4.3.1.1

methylamine + fumarate = N-methylaspartic acid

691802

6wng, 3D-view

4.3.1.1

fumaric acid + NH3 = L-aspartic acid

657547, 658403

6wng, 3D-view

1.3.5.1

12 entries

1.3.5.4

9 entries

1.3.98.1

6 entries

1.4.3.16

2 entries

2.8.3.18

2 entries

3.5.1.3

2 entries

4.1.99.11

30 entries

4.2.1.2

12 entries

4.2.1.34

2 entries

4.3.1.1

9 entries

4.3.1.2

fumarate + NH3 = ?

729057

-

4.3.2.1

arginine + fumarate = argininosuccinate

679780

6ien, 3D-view

4.3.2.1

fumarate + arginine = argininosuccinate

710563

6ien, 3D-view

4.3.2.1

fumarate + L-Arg = argininosuccinate

34429, 34443, 34424, 34426, 34436

6ien, 3D-view

4.3.2.1

fumarate + L-arginine = 2-(Nomega-L-arginino)succinate

729518

6ien, 3D-view

4.3.2.1

fumarate + L-canavanine = ?

34436

6ien, 3D-view

4.3.2.2

fumarate + AMP = N6-(1,2-dicarboxyethyl)AMP

34458, 1541, 34451

2ptq, 3D-view

4.3.2.2

fumarate + AMP = N6-(1,2-dicarboxyethyl)AMP

34458, 1541, 34451

2vd6, 3D-view

4.3.2.2

fumarate + AMP = N6-(1,2-dicarboxyethyl)AMP

34458, 1541, 34451

5hw2, 3D-view

4.3.2.2

fumarate + AMP = N6-(1,2-dicarboxyethyl)AMP

34458, 1541, 34451

5nx9, 3D-view

4.3.2.2

fumarate + AMP = N6-(1,2-dicarboxyethyl)AMP

34458, 1541, 34451

5nxa, 3D-view

4.3.2.1

5 entries

4.3.2.2

5 entries

6.2.1.17

ATP + fumarate + CoA = AMP + diphosphate + fumaroyl-CoA

656

-

6.2.1.B11

ATP + fumarate + CoA = ADP + phosphate + fumaryl-CoA

651712

-

6.3.2.46

ATP + fumarate + (2S)-2,3-diaminopropionate = AMP + diphosphate + (2E)-4-[(2-amino-2-carboxyethyl)amino]-4-oxobut-2-enoate

729202

-

Product in Enzyme-catalyzed Reactions (166 results)

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Show Product (166 entries)

EC NUMBER

REACTION

REACTION DIAGRAM

LITERATURE

ENZYME 3D STRUCTURE

1.14.18.3

methane + succinate + O2 = methanol + fumarate + H2O

-

-

1.3.1.6

succinate + NAD+ = fumarate + NADH + H+

-

-

1.3.5.1

succinate + 1,4-naphthoquinone = fumarate + 1,4-naphthoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 1-methoxy-5-methylphenazinium methyl sulfate = fumarate + ?

-

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-ethyl-6-methyl-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-ethyl-6-methyl-1,4-benzoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-methyl-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-methyl-1,4-benzohydroquinone

391104

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-methyl-6-(3,7-dimethyl-2,6-octadienyl)-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-methyl-6-(3,7-dimethyl-2,6-octadienyl)-1,4-benzoquinol

391129

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinol

391148,

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-methyl-6-geranyl-1,4-benzoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinone = fumarate + 2,3-dimethoxy-5-methyl-6-pentyl-1,4-benzoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 2,3-dimethyl-1,4-naphthoquinone = fumarate + 2,3-dimethyl-1,4-naphthoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 2,6-dichlorophenol indophenol = fumarate + reduced 2,6-dichlorophenol indophenol

-

5xmj, 3D-view

1.3.5.1

succinate + 2,6-dichlorophenolindophenol = fumarate + reduced 2,6-dichlorophenolindophenol

-

5xmj, 3D-view

1.3.5.1

succinate + 2-ethyl-3-methyl-1,4-naphthoquinone = fumarate + 2-ethyl-3-methyl-1,4-naphthoquinol

-

5xmj, 3D-view

1.3.5.1

succinate + 3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinone = fumarate + 3-azido-2-methyl-5-methoxy-6-geranyl-1,4-benzoquinol

391133

5xmj, 3D-view

1.3.5.1

succinate + acceptor = fumarate + reduced acceptor

-

5xmj, 3D-view

1.3.5.1

succinate + benzyl viologen = fumarate + reduced benzyl viologen

-

5xmj, 3D-view

1.3.5.1

succinate + caldariellaquinone = fumarate + caldariellaquinol

-

5xmj, 3D-view

1.3.5.1

succinate + decylubiquinone = fumarate + ?

-

5xmj, 3D-view

1.3.5.1

succinate + decylubiquinone = fumarate + decylubiquinol

-

5xmj, 3D-view

1.3.5.1

succinate + decylubiquinone = fumarate + reduced decylubiquinone

-

5xmj, 3D-view

1.3.5.1

succinate + duroquinone = fumarate + duroquinol

-

5xmj, 3D-view

1.3.5.1

succinate + electron acceptor = fumarate + reduced acceptor

-

5xmj, 3D-view

1.3.5.1

succinate + FAD = fumarate + FADH2

-

5xmj, 3D-view

1.3.5.1

succinate + ferricyanide = fumarate + ferrocyanide

-

5xmj, 3D-view

1.3.5.1

succinate + ferrocyanide = fumarate + ferricyanide

-

5xmj, 3D-view

1.3.5.1

succinate + menadione = fumarate + menadiol

-

5xmj, 3D-view

1.3.5.1

succinate + menaquinone = fumarate + menaquinol

-

5xmj, 3D-view

1.3.5.1

succinate + nitro blue tetrazolium = fumarate + formazan

-

5xmj, 3D-view

1.3.5.1

succinate + oxidised 2,6-dichlorophenol indophenol = fumarate + reduced 2,6-dichlorophenol indophenol

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized 2,6-dichlorophenolindophenol = fumarate + reduced 2,6-dichloroindophenol

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized 2,6-dichlorophenolindophenol = fumarate + reduced 2,6-dichlorophenolindophenol

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized benzyl viologen = fumarate + reduced benzyl viologen

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized N,N,N',N'-tetramethyl-4-phenylenediamine = fumarate + reduced N,N,N',N'-tetramethyl-4-phenylenediamine

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized phenazine ethosulfate = fumarate + reduced phenazine ethosulfate

-

5xmj, 3D-view

1.3.5.1

succinate + oxidized phenazine methosulfate = fumarate + reduced phenazine methosulfate

-

5xmj, 3D-view

1.3.5.1

succinate + phenazine ethosulfate = fumarate + reduced phenazine ethosulfate

-

5xmj, 3D-view

1.3.5.1

succinate + phenazine methosulfate = fumarate + ?

-

5xmj, 3D-view

1.3.5.1

succinate + phenazine methosulfate = fumarate + reduced phenazine methosulfate

-

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone = fumarate + ubiquinol

, 391134, 391143, 391086, 391132, 391133, 391137, 391139, 391148, 2877, 391082, 391120, 391123, 391136, 391126, 391114, 391080, 391128, 391146

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone-1 = fumarate + ubiquinol

-

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone-1 = fumarate + ubiquinol-1

-

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone-2 = fumarate + ubiquinol

-

5xmj, 3D-view

1.3.5.1

succinate + ubiquinone-8 = fumarate + ubiquinol-8

-

5xmj, 3D-view

1.3.5.1

succinate + WST-1 = fumarate + reduced WST-1

-

5xmj, 3D-view

1.3.5.1

ubiquinone-1 + succinate = ubiquinol + fumarate

-

5xmj, 3D-view

1.3.5.1

ubiquinone-1 + succinate = ubiquinol-1 + fumarate

-

5xmj, 3D-view

1.3.5.4

succinate + a menaquinone = fumarate + a menaquinol

-

-

1.3.5.4

succinate + a quinone = fumarate + a quinol

-

-

1.3.5.4

succinate + ferricyanide = fumarate + ferrocyanide

-

-

1.3.5.4

succinate + menaquinone = fumarate + menaquinol

-

-

1.3.5.4

succinate + phenazine methosulfate + 2,6-dichlorophenolindophenol = fumarate + ?

-

-

1.3.5.4

succinate + phenazine methosulfate = fumarate + reduced phenazine methosulfate

-

-

1.3.5.4

succinate + rhodoquinone = fumarate + rhodoquinol

-

-

1.3.5.4

succinate + ubiquinone = fumarate + ubiquinol

-

-

1.3.5.1

45 entries

1.3.5.4

8 entries

3.5.5.1

fumaronitrile + H2O = fumaric acid + NH3

-

-

3.5.5.5

fumaronitrile + H2O = fumaric acid + NH3

-

-

3.5.5.7

fumaronitrile + H2O = fumarate + NH3

-

-

3.5.5.7

fumaronitrile + 4 H2O = fumaric acid + 2 NH3

-

-

3.5.5.7

fumaronitrile + H2O = fumaric acid + NH3

-

-

3.5.5.7

3 entries

3.7.1.2

4-fumarylacetoacetate + H2O = acetoacetate + fumarate

289257, , 289247, 289240, 289245, 289241, 289242, 289246

1qco, 3D-view

3.7.1.20

fumarylpyruvate + H2O = fumarate + pyruvate

-

-

3.7.1.20

fumarylpyruvate + H2O = fumarate + pyruvate + H+

-

-

3.7.1.5

3-fumarylpyruvate + H2O = fumarate + pyruvate

-

-

3.7.1.5

fumarylpyruvate + H2O = fumarate + pyruvate

-

-

3.7.1.20

2 entries

3.7.1.5

2 entries

4.1.1.112

fumarylpyruvate + H2O = fumarate + pyruvate + H+

-

-

4.1.99.11

benzylsuccinate = toluene + fumarate

-

5bwd, 3D-view

4.1.99.11

benzylsuccinate = toluene + fumarate

-

5bwe, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

33762, , 33748, 33771, 33752, 33745, 33769, 33751, 33763, 33767, 653600

4apb, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

33762, , 33748, 33771, 33752, 33745, 33769, 33751, 33763, 33767, 653600

6uqn, 3D-view

4.2.1.2

(S)-malate = fumarate + H2O

33762, , 33748, 33771, 33752, 33745, 33769, 33751, 33763, 33767, 653600

7c18, 3D-view

4.2.1.2

L-malate = fumarate + H2O

-

4apb, 3D-view

4.2.1.2

L-malate = fumarate + H2O

-

6uqn, 3D-view

4.2.1.2

L-malate = fumarate + H2O

-

7c18, 3D-view

4.2.1.2

S-malate = fumarate + H2O

-

4apb, 3D-view

4.2.1.2

S-malate = fumarate + H2O

-

6uqn, 3D-view

4.2.1.2

S-malate = fumarate + H2O

-

7c18, 3D-view

4.1.99.11

2 entries

4.2.1.2

9 entries

4.2.1.34

(S)-malate = fumarate + H2O

, 5666, 5668, 5667

-

4.2.99.12

carboxymethyloxysuccinate = fumarate + glycolate

34158

-

4.3.1.1

L-aspartate = fumarate + NH3

649554, , 649266, 6030, 650750, 650751, 651803, 5997, 6002, 6005, 6008, 6009, 6012, 6016, 6017, 6018, 6019, 6021, 6022, 6023, 6024, 6028, 6007, 6013, 6029, 6010, 6027, 5998, 6026, 5999, 6000, 6001, 6003, 6004, 6006, 6011, 6014, 6020, 6025, 6015

6wng, 3D-view

4.3.1.2

(2S)-2-hydrazinosuccinic acid = fumarate + hydrazine

6061

-

4.3.1.2

(2S)-aspartate = fumarate + NH3

6064

-

4.3.1.2

(2S)-N,N-dimethylaspartic acid = fumarate + dimethylamine

6061

-

4.3.1.2

(2S)-N-ethylaspartic acid = fumarate + ethylamine

6061

-

4.3.1.2

(2S)-N-hydroxyaspartic acid = fumarate + hydroxylamine

6061

-

4.3.1.2

(2S)-N-methoxyaspartic acid = fumarate + methoxylamine

6061

-

4.3.1.2

(2S)-N-methylaspartic acid = fumarate + methylamine

6061

-

4.3.1.2

(S)-aspartate = fumarate + NH3

653208

-

4.3.1.2

L-aspartate = fumarate + NH3

, 6055, 6056, 6053

-

4.3.1.2

9 entries

4.3.1.3

L-aspartate = fumarate + NH3

-

-

4.3.2.1

(Nomega-L-arginino)succinate = fumarate + L-arginine

650042, 650043, 650800, 652692, , 650743, 651195, 652664, 653358, 652321, 651343, 650920

6ien, 3D-view

4.3.2.1

2-(Nomega-L-arginino)succinate = fumarate + L-arginine

-

6ien, 3D-view

4.3.2.1

argininosuccinate = fumarate + L-Arg

34422, 34431, 34419, 34420, 34423, 34428, , 34429, 34432, 1588, 34421, 34426, 34427, 34430, 34433, 34434, 34435, 34424, 34436, 34437

6ien, 3D-view

4.3.2.1

argininosuccinate = fumarate + L-arginine

-

6ien, 3D-view

4.3.2.1

omega-N-(L-arginino)succinate = L-arginine + fumarate

-

6ien, 3D-view

4.3.2.2

(Nomega-L-arginino)succinate = fumarate + L-arginine

-

2ptq, 3D-view

4.3.2.2

(Nomega-L-arginino)succinate = fumarate + L-arginine

-

2vd6, 3D-view

4.3.2.2

(Nomega-L-arginino)succinate = fumarate + L-arginine

-

5hw2, 3D-view

4.3.2.2

(Nomega-L-arginino)succinate = fumarate + L-arginine

-

5nx9, 3D-view

4.3.2.2

(Nomega-L-arginino)succinate = fumarate + L-arginine

-

5nxa, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

2ptq, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

2vd6, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5hw2, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5nx9, 3D-view

4.3.2.2

(S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

-

5nxa, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

2ptq, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

2vd6, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5hw2, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5nx9, 3D-view

4.3.2.2

1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole = 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide + fumarate

-

5nxa, 3D-view

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

2ptq, 3D-view

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

2vd6, 3D-view

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

5hw2, 3D-view

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

5nx9, 3D-view

4.3.2.2

2'-deoxy-succino-AMP = 2'-deoxy-AMP + fumarate

34457, 1541

5nxa, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2ptq, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2vd6, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5hw2, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nx9, 3D-view

4.3.2.2

4-(N-succino)-5-aminoimidazole-4-carboxamide ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nxa, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

2ptq, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

2vd6, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5hw2, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5nx9, 3D-view

4.3.2.2

5-aminoimidazole-(N-succinylocarboxamide) ribotide = 5-aminoimidazole-4-carboxamide ribotide + fumarate

-

5nxa, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2ptq, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

2vd6, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5hw2, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nx9, 3D-view

4.3.2.2

5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide = 5-aminoimidazole-4-carboxamide ribonucleotide + fumarate

-

5nxa, 3D-view

4.3.2.2

8-aza-succino-AMP = 8-aza-AMP + fumarate

1541

2ptq, 3D-view

4.3.2.2

8-aza-succino-AMP = 8-aza-AMP + fumarate

1541

2vd6, 3D-view

4.3.2.2

8-aza-succino-AMP = 8-aza-AMP + fumarate

1541

5hw2, 3D-view

4.3.2.2

8-aza-succino-AMP = 8-aza-AMP + fumarate

1541

5nx9, 3D-view

4.3.2.2

8-aza-succino-AMP = 8-aza-AMP + fumarate

1541

5nxa, 3D-view

4.3.2.2

adenylosuccinate 2',3'-acyclic dialcohol = adenylic 2',3'-acyclic dialcohol + fumarate

-

2ptq, 3D-view

4.3.2.2

adenylosuccinate 2',3'-acyclic dialcohol = adenylic 2',3'-acyclic dialcohol + fumarate

-

2vd6, 3D-view

4.3.2.2

adenylosuccinate 2',3'-acyclic dialcohol = adenylic 2',3'-acyclic dialcohol + fumarate

-

5hw2, 3D-view

4.3.2.2

adenylosuccinate 2',3'-acyclic dialcohol = adenylic 2',3'-acyclic dialcohol + fumarate

-

5nx9, 3D-view

4.3.2.2

adenylosuccinate 2',3'-acyclic dialcohol = adenylic 2',3'-acyclic dialcohol + fumarate

-

5nxa, 3D-view

4.3.2.2

adenylosuccinate = adenosine monophosphate + fumarate

-

2ptq, 3D-view

4.3.2.2

adenylosuccinate = adenosine monophosphate + fumarate

-

2vd6, 3D-view

4.3.2.2

adenylosuccinate = adenosine monophosphate + fumarate

-

5hw2, 3D-view

4.3.2.2

adenylosuccinate = adenosine monophosphate + fumarate

-

5nx9, 3D-view

4.3.2.2

adenylosuccinate = adenosine monophosphate + fumarate

-

5nxa, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

2ptq, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

2vd6, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5hw2, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5nx9, 3D-view

4.3.2.2

adenylosuccinate = AMP + fumarate

-

5nxa, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

, 34449, 34450, 1538, 34458, 34454, 1541, 34451

2ptq, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

, 34449, 34450, 1538, 34458, 34454, 1541, 34451

2vd6, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

, 34449, 34450, 1538, 34458, 34454, 1541, 34451

5hw2, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

, 34449, 34450, 1538, 34458, 34454, 1541, 34451

5nx9, 3D-view

4.3.2.2

N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP

, 34449, 34450, 1538, 34458, 34454, 1541, 34451

5nxa, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

2ptq, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

2vd6, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5hw2, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5nx9, 3D-view

4.3.2.2

phosphoribosylsuccinyl-aminoimidazole carboxamide = phosphoribosylaminoimidazole carboxamide + fumarate

-

5nxa, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

2ptq, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

2vd6, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5hw2, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5nx9, 3D-view

4.3.2.2

succinyladenosine monophosphate = AMP + fumarate

-

5nxa, 3D-view

4.3.2.1

5 entries

4.3.2.2

70 entries

5.2.1.1

Maleate = Fumarate

2451, 2452, 2455, 650608, 2450, , 2453, 2454, 2456

-

Enzyme Cofactor/Cosubstrate (1 result)

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Show Cofactor (1 entry)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.3.5.1

activation

391082

5xmj, 3D-view

Activator in Enzyme-catalyzed Reactions (51 results)

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Show Activating Compound (51 entries)

EC NUMBER

COMMENTARY

LITERATURE

ENZYME 3D STRUCTURE

1.1.1.202

25% activation of the enzyme, enhances the production of 1,3-propanediol from glycerol and the glycerol consumption in vivo

664422

-

1.1.1.37

the reductive reaction catalysed by the enzyme is activated by fumarate. Enzyme activity rises approximately 170 and 190% with the addition of 1 and 10 mM fumarate, respectively

761185

1uxg, 3D-view

1.1.1.37

the reductive reaction catalysed by the enzyme is activated by fumarate. Enzyme activity rises approximately 170 and 190% with the addition of 1 and 10 mM fumarate, respectively

761185

1uxh, 3D-view

1.1.1.37

the reductive reaction catalysed by the enzyme is activated by fumarate. Enzyme activity rises approximately 170 and 190% with the addition of 1 and 10 mM fumarate, respectively

761185

1uxi, 3D-view

1.1.1.38

-

695884

1gz3, 3D-view

1.1.1.38

-

695884

7bsj, 3D-view

1.1.1.38

0.7 mM, 2.1fold activation

286693

1gz3, 3D-view

1.1.1.38

0.7 mM, 2.1fold activation

286693

7bsj, 3D-view

1.1.1.38

mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by fumarate

737754

1gz3, 3D-view

1.1.1.38

mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by fumarate

737754

7bsj, 3D-view

1.1.1.39

-

721353, 712417

1pj2, 3D-view

1.1.1.39

-

721353, 712417

1pj3, 3D-view

1.1.1.39

-

712417, 721353

1pj4, 3D-view

1.1.1.39

activates in both reaction directions synergistically with L-malate both binding at separate allosteric sites different from the active site, R105 and K143 are involved

654720

1pj2, 3D-view

1.1.1.39

activates in both reaction directions synergistically with L-malate both binding at separate allosteric sites different from the active site, R105 and K143 are involved

654720

1pj3, 3D-view

1.1.1.39

activates in both reaction directions synergistically with L-malate both binding at separate allosteric sites different from the active site, R105 and K143 are involved

654720

1pj4, 3D-view

1.1.1.39

allosteric activator

657362

1pj2, 3D-view

1.1.1.39

allosteric activator

657362

1pj3, 3D-view

1.1.1.39

allosteric activator

657362

1pj4, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site

741121

1pj2, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site

741121

1pj3, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site

741121

1pj4, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site. Arg84 is essential for fumarate activation

741121

1pj2, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site. Arg84 is essential for fumarate activation

741121

1pj3, 3D-view

1.1.1.39

Arabidopsis NAD-ME1 is strongly stimulated by fumarate. Fumarate binding turns NAD-ME1 into a hyperbolic and high substrate affinity enzyme. This effect is also observed when the allosteric site is either removed or altered. Hence, fumarate is not really an activator, but suppresses the inhibitory effect of L-malate. Binding of L-malate and fumarate at the same allosteric site. Arg84 is essential for fumarate activation

741121

1pj4, 3D-view

1.1.1.39

fumarate2- is a strong activator

286707

1pj2, 3D-view

1.1.1.39

fumarate2- is a strong activator

286707

1pj3, 3D-view

1.1.1.39

fumarate2- is a strong activator

286707

1pj4, 3D-view

1.1.1.39

stimulates

286706

1pj2, 3D-view

1.1.1.39

stimulates

286706

1pj3, 3D-view

1.1.1.39

stimulates

286706

1pj4, 3D-view

1.1.1.40

about 4fold increase of activity in the presence of 7.5 mM fumarate

697911

1gz4, 3D-view

1.1.1.40

fumarate activates at high concentrations

761332

1gz4, 3D-view

1.1.1.40

fumarate activates the NADP-ME2 forward reaction by about 15fold at 0.05 mM NADP+, but only at about 1.5fold at 0.35 mM NADP+. The trans configuration of fumarate is crucial for the activating effect

723442

1gz4, 3D-view

1.1.1.40

increases activity of the mitochondrial enzyme at low malate concentrations, no effect on the activity of the cytosolic enzyme

286734

1gz4, 3D-view

1.1.1.40

isozyme NADP-ME2 activity is highly stimulated at both low and high concentrations of 0.5 mM and 2 mM, respectively, twofold activation of at 0.5 mM

689565

1gz4, 3D-view

1.1.1.40

slight activation at low concentration

286737

1gz4, 3D-view

1.1.1.40

when assayed at malate concentrations of 0.2 mM, fumarate activates the enzyme by 80% over the control activity

700772

1gz4, 3D-view

1.1.1.37

3 entries

1.1.1.38

6 entries

1.1.1.39

21 entries

1.1.1.40

7 entries

1.14.15.4

increase of activity

285387

-

1.14.17.1

-

438607, 438626, 438603

-

1.3.5.1

activation

391082

5xmj, 3D-view

2.4.1.1

activation

488259

-

2.7.13.3

effector of DcuS

705553

-

2.7.4.3

activation

642602

-

3.1.2.2

stimulates the microsomal activity

80783

-

3.1.2.20

stimulates the microsomal activity

80783

-

3.5.3.7

5 mM, relative activity 101%

32148

-

4.1.1.49

slight activation of decarboxylation

4632

-

4.1.1.71

-

648367

-

4.1.2.4

activates

5168

-

4.1.2.4

weakly activates

5166

-

4.1.2.4

2 entries