Reference on EC 3.4.16.4 - serine-type D-Ala-D-Ala carboxypeptidase and Organism(s) Streptomyces sp. and UniProt Accession P39042
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Frere, J.M.; Moreno, R.; Ghuysen, J.M.; Perkins, H.R.; Dierickx, L.; Delcambe, L.
Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39
Biochem. J.
143
233-240
1974
Streptomyces sp., Streptomyces sp. R39
Duez, C.; Piron-Fraipont, C.; Joris, B.; Dusart, J.; Urdea, M.S; Martial, J.A.; Frere, J.M.; Ghuysen, J.M.
Primary structure of the Streptomyces R61 extracellular DD-peptidase. 1. Cloning into Streptomyces lividans and nucleotide sequence of the gene [published erratum appears in Eur J Biochem 1994 Sep 15;224(3):1079
Eur. J. Biochem.
162
509-518
1987
Streptomyces sp.
Kelly, J.A.; Knox, J.R.; Zhao, H.; Frere, J.M.; Ghuysen, J.M.
Crystallographic mapping of beta-lactams bound to a D-alanyl-D-alanine peptidase target enzyme
J. Mol. Biol.
209
281-295
1989
Streptomyces sp.
Leyh-Bouille, M.; Nguyen-Disteche, M.; Pirlot, S.; Veithen, A.; Bourguignon, C.; Ghuysen, J.M.
Streptomyces K15 DD-peptidase-catalysed reactions with suicide beta-lactam carbonyl donors [published erratum appears in Biochem J 1986 Jun 15;236(3):following 933
Biochem. J.
235
177-182
1986
Streptomyces sp.
Laurent, G.; Durant, F.; Frere, J.M.; Klein, D.; Ghuysen, J.M.
Des-, syn- and anti-oxyimino-delta 3-cephalosporins. Intrinsic reactivity and reaction with RTEM-2 serine beta-lactamase and D-alanyl-D-alanine-cleaving serine and Zn2+-containing peptidases
Biochem. J.
218
933-937
1984
Actinomadura sp., Streptomyces sp.
Georgopapadakou, N.H.; Liu, F.Y.; Ryono, D.E.; Neubeck, R.; Gordon, E.M.; Pluscec, J.
Streptomyces R61 DD-carboxypeptidase: hydrolysis of X-D-alanyl-D-alanine peptides measured by a fluorometric assay
Anal. Biochem.
137
125-128
1984
Streptomyces sp.
Frere, J.M.; Joris, B.
Penicillin-sensitive enzymes in peptidoglycan biosynthesis
CRC Crit. Rev. Microbiol.
11
299-396
1985
Actinomadura sp., Streptomyces sp.
Ghuysen, J.M.; Frere, J.M.; Leyh-Bouille, M.; Nguyen-Disteche, M.; Coyette, J.; Dusart, J.; Charlier, P.; Dive, G.; Lamotte-Brasseur, J.
Bacterial wall peptidoglycan, DD-peptidases and beta-lactam antibiotics
Scand. J. Infect. Dis.
42
17-37
1984
Actinomadura sp., Streptomyces sp.
Frere, J.M.; Klein, D.; Kelly, J.A.; Ghuysen, J.M.
Interaction between monobactams and model D-alanyl-D-alanine-cleaving peptidases
FEMS Microbiol. Lett.
21
213-217
1984
Actinomadura sp., Streptomyces sp.
-
Joris, B.; Jacques, P.; Frere, J.M.; Ghuysen, J.M.; VanBeeumen, J.
Primary structure of the Streptomyces R61 extracellular DD-peptidase. 2. Amino acid sequence data
Eur. J. Biochem.
162
519-524
1987
Streptomyces sp.
Frere, J.M.; Kelly, J.A.; Klein, D.; Ghuysen, J.M.
delta 2- and delta 3-Cephalosporins, penicillinate and 6-unsubstituted penems. Intrinsic reactivity and interaction with beta-lactamases and D-alanyl-D-alanine-cleaving serine peptidases
Biochem. J.
203
223-234
1982
Streptomyces sp., Streptomyces sp. R39
DeCoen, J.L.; Lamotte-Brasseur, J.; Ghuysen, J.M.; Frere, J.M.; Perkins, H.R.
Conformational analysis of peptide substrates and inhibitors of the Zn2+ G and serine R61 D-alanyl-D-alanine peptidases
Eur. J. Biochem.
121
221-232
1981
Streptomyces sp.
Leyh-Bouille, M.; Nguyen-Disteche, M.; Ghuysen, J.M.
On the DD-carboxypeptidase enzyme system of Streptomyces strain K15
Eur. J. Biochem.
115
579-584
1981
Streptomyces sp.
Varetto, L.; Frere, J.M.; Nguyen-Disteche, M.; Ghuysen, J.M.; Houssier, C.
The pH dependence of the active-site serine DD-peptidase of Streptomyces R61
Eur. J. Biochem.
162
525-531
1987
Streptomyces sp.
Murphy, B.P.; Pratt, R.F.
Evidence for an oxyanion hole in serine beta-lactamases and DD-peptidases
Biochem. J.
256
669-672
1988
Streptomyces sp.
Kelly, J.A.; Knox, J.R.; Moews, P.C.; Hite, G.J.; Bartolone, J.B.; Zhao, H.; Joris, B.; Frere, J.M.; Ghuysen, J.M.
2.8-A Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with beta-lactams
J. Biol. Chem.
260
6449-6458
1985
Streptomyces sp.
Frere, J.M.; Duez, C.; Ghuysen, J.M.
Occurrence of a serine residue in the penicillin-binding site of the exocellular DD-carboxy-peptidase-transpeptidase from Streptomyces R61
FEBS Lett.
70
257-260
1976
Streptomyces sp.
Van der Linden, M.P.G.; Mottl, H.; Keck, W.
Cytoplasmic high-level expression of a soluble, enzymatically active form of the Escherichia coli penicillin-binding protein 5 and purification by dye chromatography
Eur. J. Biochem.
204
197-202
1992
Streptomyces sp., Escherichia coli, Streptomyces sp. R39
Perkins, H.R.; Nieto, M.; Frere, J.M.; Leyh-Bouille, M.; Ghuysen, J.M.
Streptomyces DD-carboxypeptidases as transpeptidases. The specificity for amino compounds acting as carboxyl acceptors
Biochem. J.
131
707-718
1973
Streptomyces sp., Streptomyces sp. R39, Streptomyces sp. K11
Leyh-Bouille, M.; Coyette, J.; Ghuysen, J.M.; Idczak, J.; Perkins, H.R.; Nieto, M.
Penicillin-sensitive DD-carboxypeptidase from Streptomyces strain R 61
Biochemistry
10
2163-2170
1971
Streptomyces sp.
Kimura, Y.; Takashima, Y.; Tokumasu, Y.; Sato, M.
Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus
J. Bacteriol.
181
4696-4699
1999
Streptomyces sp., Myxococcus xanthus
Fonze, E.; Vermeire, M.; Nguyen-Disteche, M.; Brasseur, R.; Charlier, P.
The crystal structure of a penicilloyl-serine transferase of intermediate penicillin sensitivity. The DD-transpeptidase of streptomyces K15
J. Biol. Chem.
274
21853-21860
1999
Streptomyces sp. (P39042)
Palomeque-Messia, P.; Quittre, V.; Leyh-Bouille, M.; Nguyen-Disteche, M.; Gershater, C.J.L.; Dacey, I.K.; Dusart, J.; van Beeumen, J.; Ghuysen, J.M.
Secretion by overexpression and purification of the water-soluble Streptomyces K15 DD-transpeptidase/penicillin-binding protein
Biochem. J.
288
87-91
1992
Streptomyces sp.
Eng, G.Y.; Maxwell, R.J.
Effect of immobilization on the penicillin binding and reactivity properties of DD-peptidase from Streptomyces R61
J. Mol. Recognit.
9
706-714
1996
Streptomyces sp.
Cabaret, D.; Liu, J.; Wakselman, M.; Pratt, R.F.; Xu, Y.
Functionalized depsipeptides, substrates and inhibitors of beta-lactamases and DD-peptidases
Bioorg. Med. Chem. Lett.
2
757-771
1994
Streptomyces sp.
Kelly, J.A.; Kuzin, A.P.
The refined crystallographic structure of a DD-peptidase penicillin-target enzyme at 1.6 A resolution
J. Mol. Biol.
254
223-236
1995
Streptomyces sp. (P15555)
Kelly, J.A.; Waley, S.G.; Adam, M.; Frere, J.M.
Crystalline enzyme kinetics: activity of the Streptomyces R61 D-alanyl-D-alanine peptidase
Biochim. Biophys. Acta
1119
256-260
1992
Streptomyces sp.
Erpicum, T.; Granier, B.; Delcour, M.; Lenzini, V.M.; Nguyen-Disteche, M.; Dusart, J.; Frere, J.M.
Enzyme production by genetically engineered Streptomyces strains: Influence of culture conditions
Biotechnol. Bioeng.
35
719-726
1990
Streptomyces sp.
Silvaggi, N.R.; Anderson, J.W.; Brinsmade, S.R.; Pratt, R.F.; Kelly, J.A.
The crystal structure of phosphonate-inhibited D-Ala-D-Ala peptidase reveals an analogue of a tetrahedral transition state
Biochemistry
42
1199-1208
2003
Streptomyces sp. (P15555)
Rhazi, N.; Charlier, P.; Dehareng, D.; Engher, D.; Vermeire, M.; Frere, J.M.; Nguyen-Disteche, M.; Fonze, E.
Catalytic mechanism of the Streptomyces K15 DD-transpeptidase/penicillin-binding protein probed by site-directed mutagenesis and structural analysis
Biochemistry
42
2895-2906
2003
Streptomyces sp. (P39042)
Lee, W.; McDonough, M.A.; Kotra, L.P.; Li, Z.H.; Silvaggi, N.R.; Takeda, Y.; Kelly, J.A.; Mobashery, S.
A 1.2-.ANG. snapshot of the final step of bacterial cell wall biosynthesis
Proc. Natl. Acad. Sci. USA
98
1427-1431
2001
Streptomyces sp. (P15555), Streptomyces sp.
Diaz, N.; Sordo, T.L.; Suarez, D.
Insights into the base catalysis exerted by the DD-transpeptidase from Streptomyces K15: A molecular dynamics study
Biochemistry
44
3225 - 3240
2005
Streptomyces sp.
Pratt, R.F.
Substrate specificity of bacterial DD-peptidases (penicillin-binding proteins)
Cell. Mol. Life Sci.
65
2138-2155
2008
Bacillus subtilis, Caulobacter vibrioides, Streptomyces sp., Streptococcus pneumoniae, Escherichia coli, Haemophilus influenzae, Staphylococcus aureus, Neisseria gonorrhoeae, Streptomyces sp. R61, Streptomyces sp. K15
Hargis, J.; Vankayala, S.; White, J.; Woodcock, H.
Identification and characterization of noncovalent interactions that drive binding and specificity in DD-peptidases and beta-lactamases
J. Chem. Theory Comput.
10
855-864
2014
Streptomyces sp. (P15555)